The role of the KRSIK motif of human angiogenin in heparin and DNA binding

Kwon Joo Yeo; Jun Goo Jee; Jin Wan Park; Yu Jin Lee; Kyoung Seok Ryu; Byoung Mog Kwon; Young Ho Jeon; Hae Kap Cheong

doi:10.1039/c6ra14599j

The role of the KRSIK motif of human angiogenin in heparin and DNA binding

Kwon Joo Yeo, Jun Goo Jee, Jin Wan Park, Yu Jin Lee, Kyoung Seok Ryu, Byoung Mog Kwon, Young Ho Jeon, Hae Kap Cheong

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Abstract

The positively charged surface with a ⁵⁰KRSIK⁵⁴ motif is the main interaction site of hAng for both heparin and DNA binding, providing an insight into the potential role of the ⁵⁰KRSIK⁵⁴ motif for the internalization and promoter binding of hAng, which is essential for the regulation of angiogenesis.

Original language	English
Pages (from-to)	82644-82647
Number of pages	4
Journal	RSC Advances
Volume	6
Issue number	86
DOIs	https://doi.org/10.1039/c6ra14599j
State	Published - 2016

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title = "The role of the KRSIK motif of human angiogenin in heparin and DNA binding",

abstract = "The positively charged surface with a 50KRSIK54 motif is the main interaction site of hAng for both heparin and DNA binding, providing an insight into the potential role of the 50KRSIK54 motif for the internalization and promoter binding of hAng, which is essential for the regulation of angiogenesis.",

author = "Yeo, {Kwon Joo} and Jee, {Jun Goo} and Park, {Jin Wan} and Lee, {Yu Jin} and Ryu, {Kyoung Seok} and Kwon, {Byoung Mog} and Jeon, {Young Ho} and Cheong, {Hae Kap}",

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AU - Yeo, Kwon Joo

AU - Jee, Jun Goo

AU - Park, Jin Wan

AU - Lee, Yu Jin

AU - Ryu, Kyoung Seok

AU - Kwon, Byoung Mog

AU - Jeon, Young Ho

AU - Cheong, Hae Kap

PY - 2016

Y1 - 2016

N2 - The positively charged surface with a 50KRSIK54 motif is the main interaction site of hAng for both heparin and DNA binding, providing an insight into the potential role of the 50KRSIK54 motif for the internalization and promoter binding of hAng, which is essential for the regulation of angiogenesis.

AB - The positively charged surface with a 50KRSIK54 motif is the main interaction site of hAng for both heparin and DNA binding, providing an insight into the potential role of the 50KRSIK54 motif for the internalization and promoter binding of hAng, which is essential for the regulation of angiogenesis.

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U2 - 10.1039/c6ra14599j

DO - 10.1039/c6ra14599j

M3 - Article

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VL - 6

SP - 82644

EP - 82647

JO - RSC Advances

JF - RSC Advances

IS - 86

ER -

The role of the KRSIK motif of human angiogenin in heparin and DNA binding

Abstract

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