The somatostatin receptors in the normal and epileptic hippocampus of the gerbil: Subtype-specific localization and its alteration

Tae Cheon Kang; Sung Jin An; Seung Kook Park; In Koo Hwang; Myung Oak Seo; Hyun Sook Kim; Jung Hoon Kang; Oh Shin Kwon; Moo Ho Won

doi:10.1016/S0006-8993(03)03192-5

The somatostatin receptors in the normal and epileptic hippocampus of the gerbil: Subtype-specific localization and its alteration

Tae Cheon Kang, Sung Jin An, Seung Kook Park, In Koo Hwang, Myung Oak Seo, Hyun Sook Kim, Jung Hoon Kang, Oh Shin Kwon, Moo Ho Won

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We investigated the distribution of somatostatin receptors (SSTs) in the hippocampi of SR (seizure-resistant) and SS (seizure-sensitive) gerbils in order to characterize the alterations in SST expressions induced by seizure activity. SST2A immunodensity in the hippocampus of SS gerbils was lower than that of SR gerbils, though its localization in the hippocampus was similar in both SR and SS gerbils. SST3 immunodensity in the hippocampus of SS gerbils was lower than in SR gerbils. In SR gerbils, strong SST4 immunoreactivity was detected in the dentate gyrus and in the CA3 region, in contrast little immunoreactivity was detected in these regions in SS gerbils. In SR and SS gerbils, the strong SST5 immunoreactivity in the hippocampus was also detected in the stratum oriens of the CA2-3 regions and the septal area of CA1 region. However, SST5 immunodensity in the stratum radiatum in SS gerbils was lower than in SR gerbils. These results are the first comprehensive description of the distribution of SSTs in the normal and epileptic hippocampus of gerbils, and suggest that these alterations in the hippocampus of the SS gerbil may be related with a regulatory mechanism for seizure activity in these seizure prone animals.

Original language	English
Pages (from-to)	91-102
Number of pages	12
Journal	Brain Research
Volume	986
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(03)03192-5
State	Published - 3 Oct 2003

Keywords

Epilepsy
Hippocampus
Mongolian gerbil
Somatostatin
Somatostatin receptor

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10.1016/S0006-8993(03)03192-5

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title = "The somatostatin receptors in the normal and epileptic hippocampus of the gerbil: Subtype-specific localization and its alteration",

abstract = "We investigated the distribution of somatostatin receptors (SSTs) in the hippocampi of SR (seizure-resistant) and SS (seizure-sensitive) gerbils in order to characterize the alterations in SST expressions induced by seizure activity. SST2A immunodensity in the hippocampus of SS gerbils was lower than that of SR gerbils, though its localization in the hippocampus was similar in both SR and SS gerbils. SST3 immunodensity in the hippocampus of SS gerbils was lower than in SR gerbils. In SR gerbils, strong SST4 immunoreactivity was detected in the dentate gyrus and in the CA3 region, in contrast little immunoreactivity was detected in these regions in SS gerbils. In SR and SS gerbils, the strong SST5 immunoreactivity in the hippocampus was also detected in the stratum oriens of the CA2-3 regions and the septal area of CA1 region. However, SST5 immunodensity in the stratum radiatum in SS gerbils was lower than in SR gerbils. These results are the first comprehensive description of the distribution of SSTs in the normal and epileptic hippocampus of gerbils, and suggest that these alterations in the hippocampus of the SS gerbil may be related with a regulatory mechanism for seizure activity in these seizure prone animals.",

keywords = "Epilepsy, Hippocampus, Mongolian gerbil, Somatostatin, Somatostatin receptor",

author = "Kang, {Tae Cheon} and An, {Sung Jin} and Park, {Seung Kook} and Hwang, {In Koo} and Seo, {Myung Oak} and Kim, {Hyun Sook} and Kang, {Jung Hoon} and Kwon, {Oh Shin} and Won, {Moo Ho}",

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T1 - The somatostatin receptors in the normal and epileptic hippocampus of the gerbil

T2 - Subtype-specific localization and its alteration

AU - Kang, Tae Cheon

AU - An, Sung Jin

AU - Park, Seung Kook

AU - Hwang, In Koo

AU - Seo, Myung Oak

AU - Kim, Hyun Sook

AU - Kang, Jung Hoon

AU - Kwon, Oh Shin

AU - Won, Moo Ho

PY - 2003/10/3

Y1 - 2003/10/3

N2 - We investigated the distribution of somatostatin receptors (SSTs) in the hippocampi of SR (seizure-resistant) and SS (seizure-sensitive) gerbils in order to characterize the alterations in SST expressions induced by seizure activity. SST2A immunodensity in the hippocampus of SS gerbils was lower than that of SR gerbils, though its localization in the hippocampus was similar in both SR and SS gerbils. SST3 immunodensity in the hippocampus of SS gerbils was lower than in SR gerbils. In SR gerbils, strong SST4 immunoreactivity was detected in the dentate gyrus and in the CA3 region, in contrast little immunoreactivity was detected in these regions in SS gerbils. In SR and SS gerbils, the strong SST5 immunoreactivity in the hippocampus was also detected in the stratum oriens of the CA2-3 regions and the septal area of CA1 region. However, SST5 immunodensity in the stratum radiatum in SS gerbils was lower than in SR gerbils. These results are the first comprehensive description of the distribution of SSTs in the normal and epileptic hippocampus of gerbils, and suggest that these alterations in the hippocampus of the SS gerbil may be related with a regulatory mechanism for seizure activity in these seizure prone animals.

AB - We investigated the distribution of somatostatin receptors (SSTs) in the hippocampi of SR (seizure-resistant) and SS (seizure-sensitive) gerbils in order to characterize the alterations in SST expressions induced by seizure activity. SST2A immunodensity in the hippocampus of SS gerbils was lower than that of SR gerbils, though its localization in the hippocampus was similar in both SR and SS gerbils. SST3 immunodensity in the hippocampus of SS gerbils was lower than in SR gerbils. In SR gerbils, strong SST4 immunoreactivity was detected in the dentate gyrus and in the CA3 region, in contrast little immunoreactivity was detected in these regions in SS gerbils. In SR and SS gerbils, the strong SST5 immunoreactivity in the hippocampus was also detected in the stratum oriens of the CA2-3 regions and the septal area of CA1 region. However, SST5 immunodensity in the stratum radiatum in SS gerbils was lower than in SR gerbils. These results are the first comprehensive description of the distribution of SSTs in the normal and epileptic hippocampus of gerbils, and suggest that these alterations in the hippocampus of the SS gerbil may be related with a regulatory mechanism for seizure activity in these seizure prone animals.

KW - Epilepsy

KW - Hippocampus

KW - Mongolian gerbil

KW - Somatostatin

KW - Somatostatin receptor

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SN - 0006-8993

VL - 986

SP - 91

EP - 102

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

The somatostatin receptors in the normal and epileptic hippocampus of the gerbil: Subtype-specific localization and its alteration

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Keywords

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