The study of doxorubicin and its interaction with adenine by UV-resonance Raman spectroscopy

Chul Jae Lee; Maeng Joon Jung

doi:10.5012/jkcs.2008.52.2.118

The study of doxorubicin and its interaction with adenine by UV-resonance Raman spectroscopy

Chul Jae Lee, Maeng Joon Jung

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

Abstract

The interaction of the antitumour agent, doxorubicin, with adenine is investigated in an aqueous solution at a concentration of 10^-3-10^-4 with volume ratios of 1:2. A UV-resonance Raman spectroscopy and surface enhanced Raman spectroscopy are used to determine the binding sites of doxorubicin to adenine and the structural variations of doxorubicin-adenine complexes in an aqueous solution. We identified that the possibilities of doxorubicin interacted with the N7 positions of adenine.

Original language	English
Pages (from-to)	118-123
Number of pages	6
Journal	Journal of the Korean Chemical Society
Volume	52
Issue number	2
DOIs	https://doi.org/10.5012/jkcs.2008.52.2.118
State	Published - 20 Apr 2008

Keywords

Adenine
Doxorubicin
Guanine
Surface enhanced Raman spectroscopy
UV-resonance Raman spectroscopy

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10.5012/jkcs.2008.52.2.118

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The study of doxorubicin and its interaction with adenine by UV-resonance Raman spectroscopy

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