Therapeutic effects of human mesenchymal stem cells in a mouse model of cerebellar ataxia with neuroinflammation

Youngpyo Nam; Dongyeong Yoon; Jungwan Hong; Min Sung Kim; Tae Yong Lee; Kyung Suk Kim; Ho Won Lee; Kyoungho Suk; Sang Ryong Kim

doi:10.3390/jcm9113654

Therapeutic effects of human mesenchymal stem cells in a mouse model of cerebellar ataxia with neuroinflammation

Youngpyo Nam, Dongyeong Yoon, Jungwan Hong, Min Sung Kim, Tae Yong Lee, Kyung Suk Kim, Ho Won Lee, Kyoungho Suk, Sang Ryong Kim

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Cerebellar ataxias (CAs) are neurological diseases characterized by loss of muscle coordination that is a result of damage and inflammation to the cerebellum. Despite considerable efforts in basic and clinical research, most CAs are currently incurable. In this study, we evaluated the therapeutic potential of human mesenchymal stem cells (hMSCs) against CAs associated with neuroinflammation. We observed that hMSC treatment significantly inhibited the symptoms of ataxia in lipopolysaccharide (LPS)-induced inflammatory CA (ICA) mice, which were recently reported as a potential animal model of ICA, through the anti-inflammatory effect of hMSC-derived TNFα-stimulated gene-6 (TSG-6), the protection of Purkinje cells by inhibition of apoptosis, and the modulatory effect for microglial M2 polarization. Thus, our results suggest that hMSC treatment may be an effective therapeutic approach for preventing or improving ataxia symptoms.

Original language	English
Article number	3654
Pages (from-to)	1-18
Number of pages	18
Journal	Journal of Clinical Medicine
Volume	9
Issue number	11
DOIs	https://doi.org/10.3390/jcm9113654
State	Published - Nov 2020

Keywords

Cerebellar ataxia
Lipopolysaccharide
Mesenchymal stem cell
Microglia
Neuroinflammation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/jcm9113654

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title = "Therapeutic effects of human mesenchymal stem cells in a mouse model of cerebellar ataxia with neuroinflammation",

abstract = "Cerebellar ataxias (CAs) are neurological diseases characterized by loss of muscle coordination that is a result of damage and inflammation to the cerebellum. Despite considerable efforts in basic and clinical research, most CAs are currently incurable. In this study, we evaluated the therapeutic potential of human mesenchymal stem cells (hMSCs) against CAs associated with neuroinflammation. We observed that hMSC treatment significantly inhibited the symptoms of ataxia in lipopolysaccharide (LPS)-induced inflammatory CA (ICA) mice, which were recently reported as a potential animal model of ICA, through the anti-inflammatory effect of hMSC-derived TNFα-stimulated gene-6 (TSG-6), the protection of Purkinje cells by inhibition of apoptosis, and the modulatory effect for microglial M2 polarization. Thus, our results suggest that hMSC treatment may be an effective therapeutic approach for preventing or improving ataxia symptoms.",

keywords = "Cerebellar ataxia, Lipopolysaccharide, Mesenchymal stem cell, Microglia, Neuroinflammation",

author = "Youngpyo Nam and Dongyeong Yoon and Jungwan Hong and Kim, {Min Sung} and Lee, {Tae Yong} and Kim, {Kyung Suk} and Lee, {Ho Won} and Kyoungho Suk and Kim, {Sang Ryong}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = nov,

doi = "10.3390/jcm9113654",

language = "English",

volume = "9",

pages = "1--18",

journal = "Journal of Clinical Medicine",

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T1 - Therapeutic effects of human mesenchymal stem cells in a mouse model of cerebellar ataxia with neuroinflammation

AU - Nam, Youngpyo

AU - Yoon, Dongyeong

AU - Hong, Jungwan

AU - Kim, Min Sung

AU - Lee, Tae Yong

AU - Kim, Kyung Suk

AU - Lee, Ho Won

AU - Suk, Kyoungho

AU - Kim, Sang Ryong

PY - 2020/11

Y1 - 2020/11

N2 - Cerebellar ataxias (CAs) are neurological diseases characterized by loss of muscle coordination that is a result of damage and inflammation to the cerebellum. Despite considerable efforts in basic and clinical research, most CAs are currently incurable. In this study, we evaluated the therapeutic potential of human mesenchymal stem cells (hMSCs) against CAs associated with neuroinflammation. We observed that hMSC treatment significantly inhibited the symptoms of ataxia in lipopolysaccharide (LPS)-induced inflammatory CA (ICA) mice, which were recently reported as a potential animal model of ICA, through the anti-inflammatory effect of hMSC-derived TNFα-stimulated gene-6 (TSG-6), the protection of Purkinje cells by inhibition of apoptosis, and the modulatory effect for microglial M2 polarization. Thus, our results suggest that hMSC treatment may be an effective therapeutic approach for preventing or improving ataxia symptoms.

AB - Cerebellar ataxias (CAs) are neurological diseases characterized by loss of muscle coordination that is a result of damage and inflammation to the cerebellum. Despite considerable efforts in basic and clinical research, most CAs are currently incurable. In this study, we evaluated the therapeutic potential of human mesenchymal stem cells (hMSCs) against CAs associated with neuroinflammation. We observed that hMSC treatment significantly inhibited the symptoms of ataxia in lipopolysaccharide (LPS)-induced inflammatory CA (ICA) mice, which were recently reported as a potential animal model of ICA, through the anti-inflammatory effect of hMSC-derived TNFα-stimulated gene-6 (TSG-6), the protection of Purkinje cells by inhibition of apoptosis, and the modulatory effect for microglial M2 polarization. Thus, our results suggest that hMSC treatment may be an effective therapeutic approach for preventing or improving ataxia symptoms.

KW - Cerebellar ataxia

KW - Lipopolysaccharide

KW - Mesenchymal stem cell

KW - Microglia

KW - Neuroinflammation

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U2 - 10.3390/jcm9113654

DO - 10.3390/jcm9113654

M3 - Article

AN - SCOPUS:85104496191

SN - 2077-0383

VL - 9

SP - 1

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JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 11

M1 - 3654

ER -

Therapeutic effects of human mesenchymal stem cells in a mouse model of cerebellar ataxia with neuroinflammation

Abstract

Keywords

UN SDGs

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