TY - JOUR
T1 - Thiophene-Derived Schiff Base Complexes
T2 - Synthesis, Characterization, Antimicrobial Properties, and Molecular Docking
AU - Nayab, Saira
AU - Alam, Aftab
AU - Ahmad, Nasir
AU - Khan, Sher Wali
AU - Khan, Waliullah
AU - Shams, Dilawar Farhan
AU - Shah, Muhammad Ishaq Ali
AU - Ateeq, Muhammad
AU - Shah, Said Karim
AU - Lee, Hyosun
N1 - Publisher Copyright:
© 2023 The Authors. Published by American Chemical Society.
PY - 2023/5/23
Y1 - 2023/5/23
N2 - Novel thiophene-derived Schiff base ligand DE, where DE is (E)-N1,N1-diethyl-N2-(thiophen-2-ylmethylene)ethane-1,2-diamine, and the corresponding M(II) complexes, [M(DE)X2] (M = Cu or Zn, X = Cl; M = Cd, X = Br), were prepared and structurally characterized. X-ray diffraction studies revealed that the geometry around the center of the M(II) complexes, [Zn(DE)Cl2] and [Cd(DE)Br2], could be best described as a distorted tetrahedral. In vitro antimicrobial screening of DE and its corresponding M(II) complexes, [M(DE)X2], was performed. The complexes were more potent and showed higher activities against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, fungi Candida albicans, and protozoa Leishmania major compared to the ligand. Among the studied complexes, [Cd(DE)Br2] exhibited the most promising antimicrobial activity against all the tested microbes compared to its analogs. These results were further supported by molecular docking studies. We believe that these complexes may significantly contribute to the efficient designing of metal-derived agents to treat microbial infections.
AB - Novel thiophene-derived Schiff base ligand DE, where DE is (E)-N1,N1-diethyl-N2-(thiophen-2-ylmethylene)ethane-1,2-diamine, and the corresponding M(II) complexes, [M(DE)X2] (M = Cu or Zn, X = Cl; M = Cd, X = Br), were prepared and structurally characterized. X-ray diffraction studies revealed that the geometry around the center of the M(II) complexes, [Zn(DE)Cl2] and [Cd(DE)Br2], could be best described as a distorted tetrahedral. In vitro antimicrobial screening of DE and its corresponding M(II) complexes, [M(DE)X2], was performed. The complexes were more potent and showed higher activities against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, fungi Candida albicans, and protozoa Leishmania major compared to the ligand. Among the studied complexes, [Cd(DE)Br2] exhibited the most promising antimicrobial activity against all the tested microbes compared to its analogs. These results were further supported by molecular docking studies. We believe that these complexes may significantly contribute to the efficient designing of metal-derived agents to treat microbial infections.
UR - http://www.scopus.com/inward/record.url?scp=85160929947&partnerID=8YFLogxK
U2 - 10.1021/acsomega.2c08266
DO - 10.1021/acsomega.2c08266
M3 - Article
AN - SCOPUS:85160929947
SN - 2470-1343
VL - 8
SP - 17620
EP - 17633
JO - ACS Omega
JF - ACS Omega
IS - 20
ER -