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Three dimensional flash flow microreactor for scale up production of monodisperse peg-plga nanoparticles

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

We present for the first time the production of PEG-PLGA nanoparticles in a ∼101 gram-scale (g/h) using pressure tolerant 3D parallel microfluidic system, and termed as a 3D flash flow microreactor (3D-FFM) system. The 3D-FFM system enables reproducible synthesis of polymer nanoparticles without aggregation under fast flow rate with higher ratio of polymer precursor to solvent (∼0.43), yielding 12.9 g/h production rate of monodisperse PEG-PLGA nanoparticles.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages1515-1517
Number of pages3
ISBN (Electronic)9780979806476
StatePublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: 26 Oct 201430 Oct 2014

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Conference

Conference18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/TerritoryUnited States
CitySan Antonio
Period26/10/1430/10/14

Keywords

  • Mass production
  • Nanoparticle
  • Polyimide film
  • Three dimensional microfluidic

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