Three new isoprenylated flavonoids from the root bark of morus alba

Jae Woo Jung; Ji Hae Park; Yeong Geun Lee; Kyeong Hwa Seo; Eun Ji Oh; Dae Young Lee; Dong Wook Lim; Daeseok Han; Nam In Baek

doi:10.3390/molecules21091112

Three new isoprenylated flavonoids from the root bark of morus alba

Jae Woo Jung, Ji Hae Park, Yeong Geun Lee, Kyeong Hwa Seo, Eun Ji Oh, Dae Young Lee, Dong Wook Lim, Daeseok Han, Nam In Baek

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Phytochemical investigation of the root bark of Morus alba has led to the isolation and identification of three new isoprenylated flavonoids, namely sanggenon U (1), sanggenon V (2), and sanggenon W (3), along with four known isoprenylated flavonoids: euchrenone a7 (4), sanggenon J (5), kuwanon E (6), and kuwanon S (7). All compounds were isolated by repeated silica gel (SiO2 ), octadecyl SiO2 (ODS), and Sephadex LH-20 open column chromatography. The structure of the compounds were determined based on spectroscopic analyses, including nuclear magnetic resonance (NMR), mass spectrometry (MS), circular dichroism (CD), and infrared (IR). In addition, compounds 1-4 were isolated for the first time from the root bark of M. alba in this study.

Original language	English
Article number	1112
Journal	Molecules
Volume	21
Issue number	9
DOIs	https://doi.org/10.3390/molecules21091112
State	Published - Sep 2016

Keywords

Isoprenylated flavonoids
Morus alba
Root bark
Sanggenon U
Sanggenon V
Sanggenon W

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10.3390/molecules21091112

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title = "Three new isoprenylated flavonoids from the root bark of morus alba",

abstract = "Phytochemical investigation of the root bark of Morus alba has led to the isolation and identification of three new isoprenylated flavonoids, namely sanggenon U (1), sanggenon V (2), and sanggenon W (3), along with four known isoprenylated flavonoids: euchrenone a7 (4), sanggenon J (5), kuwanon E (6), and kuwanon S (7). All compounds were isolated by repeated silica gel (SiO2 ), octadecyl SiO2 (ODS), and Sephadex LH-20 open column chromatography. The structure of the compounds were determined based on spectroscopic analyses, including nuclear magnetic resonance (NMR), mass spectrometry (MS), circular dichroism (CD), and infrared (IR). In addition, compounds 1-4 were isolated for the first time from the root bark of M. alba in this study.",

keywords = "Isoprenylated flavonoids, Morus alba, Root bark, Sanggenon U, Sanggenon V, Sanggenon W",

author = "Jung, \{Jae Woo\} and Park, \{Ji Hae\} and Lee, \{Yeong Geun\} and Seo, \{Kyeong Hwa\} and Oh, \{Eun Ji\} and Lee, \{Dae Young\} and Lim, \{Dong Wook\} and Daeseok Han and Baek, \{Nam In\}",

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year = "2016",

month = sep,

doi = "10.3390/molecules21091112",

language = "English",

volume = "21",

journal = "Molecules",

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T1 - Three new isoprenylated flavonoids from the root bark of morus alba

AU - Jung, Jae Woo

AU - Park, Ji Hae

AU - Lee, Yeong Geun

AU - Seo, Kyeong Hwa

AU - Oh, Eun Ji

AU - Lee, Dae Young

AU - Lim, Dong Wook

AU - Han, Daeseok

AU - Baek, Nam In

PY - 2016/9

Y1 - 2016/9

N2 - Phytochemical investigation of the root bark of Morus alba has led to the isolation and identification of three new isoprenylated flavonoids, namely sanggenon U (1), sanggenon V (2), and sanggenon W (3), along with four known isoprenylated flavonoids: euchrenone a7 (4), sanggenon J (5), kuwanon E (6), and kuwanon S (7). All compounds were isolated by repeated silica gel (SiO2 ), octadecyl SiO2 (ODS), and Sephadex LH-20 open column chromatography. The structure of the compounds were determined based on spectroscopic analyses, including nuclear magnetic resonance (NMR), mass spectrometry (MS), circular dichroism (CD), and infrared (IR). In addition, compounds 1-4 were isolated for the first time from the root bark of M. alba in this study.

AB - Phytochemical investigation of the root bark of Morus alba has led to the isolation and identification of three new isoprenylated flavonoids, namely sanggenon U (1), sanggenon V (2), and sanggenon W (3), along with four known isoprenylated flavonoids: euchrenone a7 (4), sanggenon J (5), kuwanon E (6), and kuwanon S (7). All compounds were isolated by repeated silica gel (SiO2 ), octadecyl SiO2 (ODS), and Sephadex LH-20 open column chromatography. The structure of the compounds were determined based on spectroscopic analyses, including nuclear magnetic resonance (NMR), mass spectrometry (MS), circular dichroism (CD), and infrared (IR). In addition, compounds 1-4 were isolated for the first time from the root bark of M. alba in this study.

KW - Isoprenylated flavonoids

KW - Morus alba

KW - Root bark

KW - Sanggenon U

KW - Sanggenon V

KW - Sanggenon W

UR - https://www.scopus.com/pages/publications/84987850924

U2 - 10.3390/molecules21091112

DO - 10.3390/molecules21091112

M3 - Article

C2 - 27563860

AN - SCOPUS:84987850924

SN - 1420-3049

VL - 21

JO - Molecules

JF - Molecules

IS - 9

M1 - 1112

ER -

Three new isoprenylated flavonoids from the root bark of morus alba

Abstract

Keywords

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