Titin-cap (TCAP) polymorphisms associated with marbling score of beef

H. S. Cheong; D. Yoon; L. H. Kim; B. L. Park; H. W. Lee; C. S. Han; E. M. Kim; H. Cho; E. R. Chung; I. Cheong; H. D. Shin

doi:10.1016/j.meatsci.2007.03.014

Titin-cap (TCAP) polymorphisms associated with marbling score of beef

H. S. Cheong, D. Yoon, L. H. Kim, B. L. Park, H. W. Lee, C. S. Han, E. M. Kim, H. Cho, E. R. Chung, I. Cheong, H. D. Shin

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15 Scopus citations

Abstract

Marbling score (MS) is the major qualitative trait that affects carcass quality in beef cattle. In this study, we examined the association between genetic polymorphisms of the titin-cap gene (TCAP) and carcass traits in Korean native cattle (also known as Hanwoo). By direct DNA sequencing in 24 unrelated Korean cattle, we identified five sequence variants in 1.2 kb of TCAP. Among them, four common polymorphic sites were selected for genotyping in the beef cattle (n = 437). Pair-wise linkage analysis with four polymorphisms showed strong linkage disequilibrium (LD), and three major haplotypes (freq. > 0.1) were constructed. Statistical analysis revealed that polymorphisms in intron1 (g.346G > A) and exon2 (g.592-597CTGCAG[Leu-Gln]insdel) showed significant association with marbling score (P^cor. = 0.003 and 0.02, respectively). One haplotype, ht2[C-G-G-del], also showed significant association with MS (P^cor. = 0.0004). Our findings suggest that polymorphisms in TCAP might be among the important genetic factors involved in carcass quality in beef cattle.

Original language	English
Pages (from-to)	257-263
Number of pages	7
Journal	Meat Science
Volume	77
Issue number	2
DOIs	https://doi.org/10.1016/j.meatsci.2007.03.014
State	Published - Oct 2007

Keywords

Cold carcass weight
Marbling score
Polymorphism
TCAP

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10.1016/j.meatsci.2007.03.014

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@article{41630708ec3347a6946a3c0236729d5f,

title = "Titin-cap (TCAP) polymorphisms associated with marbling score of beef",

abstract = "Marbling score (MS) is the major qualitative trait that affects carcass quality in beef cattle. In this study, we examined the association between genetic polymorphisms of the titin-cap gene (TCAP) and carcass traits in Korean native cattle (also known as Hanwoo). By direct DNA sequencing in 24 unrelated Korean cattle, we identified five sequence variants in 1.2 kb of TCAP. Among them, four common polymorphic sites were selected for genotyping in the beef cattle (n = 437). Pair-wise linkage analysis with four polymorphisms showed strong linkage disequilibrium (LD), and three major haplotypes (freq. > 0.1) were constructed. Statistical analysis revealed that polymorphisms in intron1 (g.346G > A) and exon2 (g.592-597CTGCAG[Leu-Gln]insdel) showed significant association with marbling score (Pcor. = 0.003 and 0.02, respectively). One haplotype, ht2[C-G-G-del], also showed significant association with MS (Pcor. = 0.0004). Our findings suggest that polymorphisms in TCAP might be among the important genetic factors involved in carcass quality in beef cattle.",

keywords = "Cold carcass weight, Marbling score, Polymorphism, TCAP",

author = "Cheong, {H. S.} and D. Yoon and Kim, {L. H.} and Park, {B. L.} and Lee, {H. W.} and Han, {C. S.} and Kim, {E. M.} and H. Cho and Chung, {E. R.} and I. Cheong and Shin, {H. D.}",

year = "2007",

month = oct,

doi = "10.1016/j.meatsci.2007.03.014",

language = "English",

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T1 - Titin-cap (TCAP) polymorphisms associated with marbling score of beef

AU - Cheong, H. S.

AU - Yoon, D.

AU - Kim, L. H.

AU - Park, B. L.

AU - Lee, H. W.

AU - Han, C. S.

AU - Kim, E. M.

AU - Cho, H.

AU - Chung, E. R.

AU - Cheong, I.

AU - Shin, H. D.

PY - 2007/10

Y1 - 2007/10

N2 - Marbling score (MS) is the major qualitative trait that affects carcass quality in beef cattle. In this study, we examined the association between genetic polymorphisms of the titin-cap gene (TCAP) and carcass traits in Korean native cattle (also known as Hanwoo). By direct DNA sequencing in 24 unrelated Korean cattle, we identified five sequence variants in 1.2 kb of TCAP. Among them, four common polymorphic sites were selected for genotyping in the beef cattle (n = 437). Pair-wise linkage analysis with four polymorphisms showed strong linkage disequilibrium (LD), and three major haplotypes (freq. > 0.1) were constructed. Statistical analysis revealed that polymorphisms in intron1 (g.346G > A) and exon2 (g.592-597CTGCAG[Leu-Gln]insdel) showed significant association with marbling score (Pcor. = 0.003 and 0.02, respectively). One haplotype, ht2[C-G-G-del], also showed significant association with MS (Pcor. = 0.0004). Our findings suggest that polymorphisms in TCAP might be among the important genetic factors involved in carcass quality in beef cattle.

AB - Marbling score (MS) is the major qualitative trait that affects carcass quality in beef cattle. In this study, we examined the association between genetic polymorphisms of the titin-cap gene (TCAP) and carcass traits in Korean native cattle (also known as Hanwoo). By direct DNA sequencing in 24 unrelated Korean cattle, we identified five sequence variants in 1.2 kb of TCAP. Among them, four common polymorphic sites were selected for genotyping in the beef cattle (n = 437). Pair-wise linkage analysis with four polymorphisms showed strong linkage disequilibrium (LD), and three major haplotypes (freq. > 0.1) were constructed. Statistical analysis revealed that polymorphisms in intron1 (g.346G > A) and exon2 (g.592-597CTGCAG[Leu-Gln]insdel) showed significant association with marbling score (Pcor. = 0.003 and 0.02, respectively). One haplotype, ht2[C-G-G-del], also showed significant association with MS (Pcor. = 0.0004). Our findings suggest that polymorphisms in TCAP might be among the important genetic factors involved in carcass quality in beef cattle.

KW - Cold carcass weight

KW - Marbling score

KW - Polymorphism

KW - TCAP

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DO - 10.1016/j.meatsci.2007.03.014

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VL - 77

SP - 257

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JO - Meat Science

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ER -

Titin-cap (TCAP) polymorphisms associated with marbling score of beef

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Keywords

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