Transcriptional regulation of fibroblast growth factor 21 expression

Kwi Hyun Bae, Jung Guk Kim, Keun Gyu Park

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Fibroblast growth factor 21 (FGF21) is an attractive target for treating metabolic disease due to its wide-ranging beneficial effects on glucose and lipid metabolism. Circulating FGF21 levels are increased in insulin-resistant states; however, endogenous FGF21 fails to improve glucose and lipid metabolism in obesity, suggesting that metabolic syndrome is an FGF21-resistant state. Therefore, transcription factors for FGF21 are potential drug targets that could increase FGF21 expression in obesity and reduce FGF21 resistance. Despite many studies on the metabolic effects of FGF21, the transcriptional regulation of FGF21 gene expression remains controversial and is not fully understood. As the FGF21 transcription factor pathway is one of the most promising targets for the treatment of metabolic syndrome, further investigation of FGF21 transcriptional regulation is required.

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalEndocrinology and Metabolism
Volume29
Issue number2
DOIs
StatePublished - 2014

Keywords

  • Diabetes mellitus
  • Fibroblast growth factor 21
  • Insulin resistance
  • Transcription factors

Fingerprint

Dive into the research topics of 'Transcriptional regulation of fibroblast growth factor 21 expression'. Together they form a unique fingerprint.

Cite this