Transgenic mouse model for breast cancer: Induction of breast cancer in novel oncogene HCCR-2 transgenic mice

Jesang Ko; Seung Min Shin; Young Mi Oh; Youn Soo Lee; Zae Yoong Ryoo; Young Han Lee; Doe Sun Na; Jin Woo Kim

doi:10.1038/sj.onc.1207356

Transgenic mouse model for breast cancer: Induction of breast cancer in novel oncogene HCCR-2 transgenic mice

Jesang Ko, Seung Min Shin, Young Mi Oh, Youn Soo Lee, Zae Yoong Ryoo, Young Han Lee, Doe Sun Na, Jin Woo Kim

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Abstract

Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node. We examined whether stabilized p53 is functional in HCCR-2 transgenic mice. Defective induction of p53 responsive genes including p21^WAF1, MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor.

Original language	English
Pages (from-to)	1950-1953
Number of pages	4
Journal	Oncogene
Volume	23
Issue number	10
DOIs	https://doi.org/10.1038/sj.onc.1207356
State	Published - 11 Mar 2004

Keywords

Breast cancer
HCCR-2
p53
Transgenic mouse

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10.1038/sj.onc.1207356

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title = "Transgenic mouse model for breast cancer: Induction of breast cancer in novel oncogene HCCR-2 transgenic mice",

abstract = "Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node. We examined whether stabilized p53 is functional in HCCR-2 transgenic mice. Defective induction of p53 responsive genes including p21WAF1, MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor.",

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author = "Jesang Ko and Shin, {Seung Min} and Oh, {Young Mi} and Lee, {Youn Soo} and Ryoo, {Zae Yoong} and Lee, {Young Han} and Na, {Doe Sun} and Kim, {Jin Woo}",

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AU - Ko, Jesang

AU - Shin, Seung Min

AU - Oh, Young Mi

AU - Lee, Youn Soo

AU - Ryoo, Zae Yoong

AU - Lee, Young Han

AU - Na, Doe Sun

AU - Kim, Jin Woo

PY - 2004/3/11

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N2 - Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node. We examined whether stabilized p53 is functional in HCCR-2 transgenic mice. Defective induction of p53 responsive genes including p21WAF1, MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor.

AB - Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node. We examined whether stabilized p53 is functional in HCCR-2 transgenic mice. Defective induction of p53 responsive genes including p21WAF1, MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor.

KW - Breast cancer

KW - HCCR-2

KW - p53

KW - Transgenic mouse

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Transgenic mouse model for breast cancer: Induction of breast cancer in novel oncogene HCCR-2 transgenic mice

Abstract

Keywords

UN SDGs

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