Transgenic mouse model for breast cancer: Induction of breast cancer in novel oncogene HCCR-2 transgenic mice

Jesang Ko; Seung Min Shin; Young Mi Oh; Youn Soo Lee; Zae Yoong Ryoo; Young Han Lee; Doe Sun Na; Jin Woo Kim

doi:10.1038/sj.onc.1207356

Transgenic mouse model for breast cancer: Induction of breast cancer in novel oncogene HCCR-2 transgenic mice

Jesang Ko, Seung Min Shin, Young Mi Oh, Youn Soo Lee, Zae Yoong Ryoo, Young Han Lee, Doe Sun Na, Jin Woo Kim

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39 Scopus citations

Abstract

Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node. We examined whether stabilized p53 is functional in HCCR-2 transgenic mice. Defective induction of p53 responsive genes including p21^WAF1, MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor.

Original language	English
Pages (from-to)	1950-1953
Number of pages	4
Journal	Oncogene
Volume	23
Issue number	10
DOIs	https://doi.org/10.1038/sj.onc.1207356
State	Published - 11 Mar 2004

Keywords

Breast cancer
HCCR-2
p53
Transgenic mouse

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10.1038/sj.onc.1207356

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title = "Transgenic mouse model for breast cancer: Induction of breast cancer in novel oncogene HCCR-2 transgenic mice",

abstract = "Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node. We examined whether stabilized p53 is functional in HCCR-2 transgenic mice. Defective induction of p53 responsive genes including p21WAF1, MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor.",

keywords = "Breast cancer, HCCR-2, p53, Transgenic mouse",

author = "Jesang Ko and Shin, \{Seung Min\} and Oh, \{Young Mi\} and Lee, \{Youn Soo\} and Ryoo, \{Zae Yoong\} and Lee, \{Young Han\} and Na, \{Doe Sun\} and Kim, \{Jin Woo\}",

year = "2004",

month = mar,

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doi = "10.1038/sj.onc.1207356",

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T1 - Transgenic mouse model for breast cancer

T2 - Induction of breast cancer in novel oncogene HCCR-2 transgenic mice

AU - Ko, Jesang

AU - Shin, Seung Min

AU - Oh, Young Mi

AU - Lee, Youn Soo

AU - Ryoo, Zae Yoong

AU - Lee, Young Han

AU - Na, Doe Sun

AU - Kim, Jin Woo

PY - 2004/3/11

Y1 - 2004/3/11

N2 - Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node. We examined whether stabilized p53 is functional in HCCR-2 transgenic mice. Defective induction of p53 responsive genes including p21WAF1, MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor.

AB - Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node. We examined whether stabilized p53 is functional in HCCR-2 transgenic mice. Defective induction of p53 responsive genes including p21WAF1, MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor.

KW - Breast cancer

KW - HCCR-2

KW - p53

KW - Transgenic mouse

UR - https://www.scopus.com/pages/publications/1842482281

U2 - 10.1038/sj.onc.1207356

DO - 10.1038/sj.onc.1207356

M3 - Article

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AN - SCOPUS:1842482281

SN - 0950-9232

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SP - 1950

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JO - Oncogene

JF - Oncogene

IS - 10

ER -

Transgenic mouse model for breast cancer: Induction of breast cancer in novel oncogene HCCR-2 transgenic mice

Abstract

Keywords

UN SDGs

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