Transition metal-free construction of trinuclear N-fused hybrid scaffolds by double nucleophilic aromatic substitution under microwave irradiation

Pham Duy Quang Dao; Ho Jin Lim; Chan Sik Cho

doi:10.1039/c9gc03410b

Transition metal-free construction of trinuclear N-fused hybrid scaffolds by double nucleophilic aromatic substitution under microwave irradiation

Pham Duy Quang Dao
, Ho Jin Lim
, Chan Sik Cho

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Treatment of 2-(2-bromoaryl)- and 2-(2-bromovinyl)benzimidazoles with 2-aminoazoles in the presence of a base under microwave irradiation triggers double C(sp²)-N coupling to form trinuclear N-fused hybrid scaffolds. A reaction pathway involving nucleophilic aromatic substitution (S_NAr) accompanied by ammonia evolution is proposed as a key step of this transition metal-free process.

Original language	English
Pages (from-to)	6590-6593
Number of pages	4
Journal	Green Chemistry
Volume	21
Issue number	24
DOIs	https://doi.org/10.1039/c9gc03410b
State	Published - 2019

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title = "Transition metal-free construction of trinuclear N-fused hybrid scaffolds by double nucleophilic aromatic substitution under microwave irradiation",

abstract = "Treatment of 2-(2-bromoaryl)- and 2-(2-bromovinyl)benzimidazoles with 2-aminoazoles in the presence of a base under microwave irradiation triggers double C(sp2)-N coupling to form trinuclear N-fused hybrid scaffolds. A reaction pathway involving nucleophilic aromatic substitution (SNAr) accompanied by ammonia evolution is proposed as a key step of this transition metal-free process.",

author = "Dao, \{Pham Duy Quang\} and Lim, \{Ho Jin\} and Cho, \{Chan Sik\}",

note = "Publisher Copyright: This journal is {\textcopyright} The Royal Society of Chemistry.",

year = "2019",

doi = "10.1039/c9gc03410b",

language = "English",

volume = "21",

pages = "6590--6593",

journal = "Green Chemistry",

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publisher = "Royal Society of Chemistry",

number = "24",

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T1 - Transition metal-free construction of trinuclear N-fused hybrid scaffolds by double nucleophilic aromatic substitution under microwave irradiation

AU - Dao, Pham Duy Quang

AU - Lim, Ho Jin

AU - Cho, Chan Sik

N1 - Publisher Copyright: This journal is © The Royal Society of Chemistry.

PY - 2019

Y1 - 2019

N2 - Treatment of 2-(2-bromoaryl)- and 2-(2-bromovinyl)benzimidazoles with 2-aminoazoles in the presence of a base under microwave irradiation triggers double C(sp2)-N coupling to form trinuclear N-fused hybrid scaffolds. A reaction pathway involving nucleophilic aromatic substitution (SNAr) accompanied by ammonia evolution is proposed as a key step of this transition metal-free process.

AB - Treatment of 2-(2-bromoaryl)- and 2-(2-bromovinyl)benzimidazoles with 2-aminoazoles in the presence of a base under microwave irradiation triggers double C(sp2)-N coupling to form trinuclear N-fused hybrid scaffolds. A reaction pathway involving nucleophilic aromatic substitution (SNAr) accompanied by ammonia evolution is proposed as a key step of this transition metal-free process.

UR - https://www.scopus.com/pages/publications/85076711531

U2 - 10.1039/c9gc03410b

DO - 10.1039/c9gc03410b

M3 - Article

AN - SCOPUS:85076711531

SN - 1463-9262

VL - 21

SP - 6590

EP - 6593

JO - Green Chemistry

JF - Green Chemistry

IS - 24

ER -

Transition metal-free construction of trinuclear N-fused hybrid scaffolds by double nucleophilic aromatic substitution under microwave irradiation

Abstract

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