Treatment of vitiligo with broad-band UVB targeted-phototherapy

Backgroud: Vitiligo is characterized by depigmentation of the skin due to melanocyte destruction. UVB has been widely used for therapy of vitiligo and reported to be an effective and safe therapeutic option. Objective: The aim of this study was to evaluate the efficacy of a self-made targeted phototherapeutic device in the treatment of vitiligo. Subjects and method: In this trial, thirty two individuals affected by vitiligo were treated once or twice a week for 6 months with targeted phototherapy. The response to treatment was evaluated by comparing the photographs which were taken during the treatment, using planimetry, and it was regarded as effective when more than 50% repigmentation was observed. Results: In general, twenty one of thirty two patients (66%) achieved repigmentation in more than 50% of the treated areas. According to the affected sites, vitiligo patches on hands and feet responded less well to the treatment. Focal and segmental vitiligo showed a better response than generalized one. Conclusion: A new therapeutic modality called targeted phototherapy was as effective as the current generalized or local phototherapies in the treatment of vitiligo.