Triterpenoid and lignan from the fruits of Cornus kousa inhibit the activities of PRL-3 and LDL-Oxidation

Dae Young Lee; Min Ho Lee; Tae Sook Jung; Byoung Mog Kwon; Nam In Baek; Yeong Deok Rho

doi:10.3839/jksabc.2010.016

Triterpenoid and lignan from the fruits of Cornus kousa inhibit the activities of PRL-3 and LDL-Oxidation

Dae Young Lee, Min Ho Lee, Tae Sook Jung, Byoung Mog Kwon, Nam In Baek, Yeong Deok Rho

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Ursolic aldehyde (1) and (+)-lariciresinol (2) were isolated from the MeOH extracted fraction of the fruits of Cornus kousa by repeated column chromatographies. The structure of the compounds were determined by spectroscopic data including nuclear magnetic resonance spectrometry, mass spectrometry and infrared spectrometry Ursolic aldehyde inhibited phosphatase of regenerating liver-3 with IC₅₀ value of 50±0.3 μM. And (+)-lariciresinol inhibited low-density lipoprotein oxidation with an IC₅₀ value of 11.9±0.5 μM.

Original language	English
Pages (from-to)	97-100
Number of pages	4
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume	53
Issue number	1
DOIs	https://doi.org/10.3839/jksabc.2010.016
State	Published - 2010

Keywords

(+)-lariciresinol
Cornus kousa
LDL-oxidation
PRL-3
Ursolic aldehyde

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10.3839/jksabc.2010.016

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title = "Triterpenoid and lignan from the fruits of Cornus kousa inhibit the activities of PRL-3 and LDL-Oxidation",

abstract = "Ursolic aldehyde (1) and (+)-lariciresinol (2) were isolated from the MeOH extracted fraction of the fruits of Cornus kousa by repeated column chromatographies. The structure of the compounds were determined by spectroscopic data including nuclear magnetic resonance spectrometry, mass spectrometry and infrared spectrometry Ursolic aldehyde inhibited phosphatase of regenerating liver-3 with IC50 value of 50±0.3 μM. And (+)-lariciresinol inhibited low-density lipoprotein oxidation with an IC50 value of 11.9±0.5 μM.",

keywords = "(+)-lariciresinol, Cornus kousa, LDL-oxidation, PRL-3, Ursolic aldehyde",

author = "Lee, {Dae Young} and Lee, {Min Ho} and Jung, {Tae Sook} and Kwon, {Byoung Mog} and Baek, {Nam In} and Rho, {Yeong Deok}",

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doi = "10.3839/jksabc.2010.016",

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T1 - Triterpenoid and lignan from the fruits of Cornus kousa inhibit the activities of PRL-3 and LDL-Oxidation

AU - Lee, Dae Young

AU - Lee, Min Ho

AU - Jung, Tae Sook

AU - Kwon, Byoung Mog

AU - Baek, Nam In

AU - Rho, Yeong Deok

PY - 2010

Y1 - 2010

N2 - Ursolic aldehyde (1) and (+)-lariciresinol (2) were isolated from the MeOH extracted fraction of the fruits of Cornus kousa by repeated column chromatographies. The structure of the compounds were determined by spectroscopic data including nuclear magnetic resonance spectrometry, mass spectrometry and infrared spectrometry Ursolic aldehyde inhibited phosphatase of regenerating liver-3 with IC50 value of 50±0.3 μM. And (+)-lariciresinol inhibited low-density lipoprotein oxidation with an IC50 value of 11.9±0.5 μM.

AB - Ursolic aldehyde (1) and (+)-lariciresinol (2) were isolated from the MeOH extracted fraction of the fruits of Cornus kousa by repeated column chromatographies. The structure of the compounds were determined by spectroscopic data including nuclear magnetic resonance spectrometry, mass spectrometry and infrared spectrometry Ursolic aldehyde inhibited phosphatase of regenerating liver-3 with IC50 value of 50±0.3 μM. And (+)-lariciresinol inhibited low-density lipoprotein oxidation with an IC50 value of 11.9±0.5 μM.

KW - (+)-lariciresinol

KW - Cornus kousa

KW - LDL-oxidation

KW - PRL-3

KW - Ursolic aldehyde

UR - http://www.scopus.com/inward/record.url?scp=79957537409&partnerID=8YFLogxK

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DO - 10.3839/jksabc.2010.016

M3 - Article

AN - SCOPUS:79957537409

SN - 1738-2203

VL - 53

SP - 97

EP - 100

JO - Journal of the Korean Society for Applied Biological Chemistry

JF - Journal of the Korean Society for Applied Biological Chemistry

IS - 1

ER -

Triterpenoid and lignan from the fruits of Cornus kousa inhibit the activities of PRL-3 and LDL-Oxidation

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Keywords

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