Triterpenoids from Fragaria ananassa calyx and their inhibitory effects on melanogenesis in B16-F10 mouse melanoma cells

Na Young Song; Jin Gyeong Cho; Dongmoon Im; Dae Young Lee; Qian Wu; Woo Duck Seo; Hee Cheol Kang; Youn Hyung Lee; Nam In Baek

doi:10.1080/14786419.2013.805330

Triterpenoids from Fragaria ananassa calyx and their inhibitory effects on melanogenesis in B16-F10 mouse melanoma cells

Na Young Song, Jin Gyeong Cho, Dongmoon Im, Dae Young Lee, Qian Wu, Woo Duck Seo, Hee Cheol Kang, Youn Hyung Lee, Nam In Baek

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Column chromatographic technology was applied to isolate six purified ursane triterpenoids from the calyx of Fragaria ananassa and they were identified on the basis of spectroscopic methods to be ursolic acid (1), pomolic acid (2), 2-oxo-pomolic acid (3), 3-O-acetyl pomolic acid (4), fupenzic acid (5) and euscaphic acid (6). This is the first study in which these compounds have been isolated from the calyx of F. ananassa. Compared to a well-known inhibitor, α-arbutin, compounds 2-6 showed a significant decrease in intracellular melanin content in B16-F10 cells, and in culture media melanin.

Original language	English
Pages (from-to)	2219-2223
Number of pages	5
Journal	Natural Product Research
Volume	27
Issue number	23
DOIs	https://doi.org/10.1080/14786419.2013.805330
State	Published - 1 Dec 2013

Keywords

Fragaria ananassa calyx
melanogenesis inhibition
ursane triterpenoid

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10.1080/14786419.2013.805330

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title = "Triterpenoids from Fragaria ananassa calyx and their inhibitory effects on melanogenesis in B16-F10 mouse melanoma cells",

abstract = "Column chromatographic technology was applied to isolate six purified ursane triterpenoids from the calyx of Fragaria ananassa and they were identified on the basis of spectroscopic methods to be ursolic acid (1), pomolic acid (2), 2-oxo-pomolic acid (3), 3-O-acetyl pomolic acid (4), fupenzic acid (5) and euscaphic acid (6). This is the first study in which these compounds have been isolated from the calyx of F. ananassa. Compared to a well-known inhibitor, α-arbutin, compounds 2-6 showed a significant decrease in intracellular melanin content in B16-F10 cells, and in culture media melanin.",

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T1 - Triterpenoids from Fragaria ananassa calyx and their inhibitory effects on melanogenesis in B16-F10 mouse melanoma cells

AU - Song, Na Young

AU - Cho, Jin Gyeong

AU - Im, Dongmoon

AU - Lee, Dae Young

AU - Wu, Qian

AU - Seo, Woo Duck

AU - Kang, Hee Cheol

AU - Lee, Youn Hyung

AU - Baek, Nam In

PY - 2013/12/1

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N2 - Column chromatographic technology was applied to isolate six purified ursane triterpenoids from the calyx of Fragaria ananassa and they were identified on the basis of spectroscopic methods to be ursolic acid (1), pomolic acid (2), 2-oxo-pomolic acid (3), 3-O-acetyl pomolic acid (4), fupenzic acid (5) and euscaphic acid (6). This is the first study in which these compounds have been isolated from the calyx of F. ananassa. Compared to a well-known inhibitor, α-arbutin, compounds 2-6 showed a significant decrease in intracellular melanin content in B16-F10 cells, and in culture media melanin.

AB - Column chromatographic technology was applied to isolate six purified ursane triterpenoids from the calyx of Fragaria ananassa and they were identified on the basis of spectroscopic methods to be ursolic acid (1), pomolic acid (2), 2-oxo-pomolic acid (3), 3-O-acetyl pomolic acid (4), fupenzic acid (5) and euscaphic acid (6). This is the first study in which these compounds have been isolated from the calyx of F. ananassa. Compared to a well-known inhibitor, α-arbutin, compounds 2-6 showed a significant decrease in intracellular melanin content in B16-F10 cells, and in culture media melanin.

KW - Fragaria ananassa calyx

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Triterpenoids from Fragaria ananassa calyx and their inhibitory effects on melanogenesis in B16-F10 mouse melanoma cells

Abstract

Keywords

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