TSC2 genetic variant and prognosis in non-small cell lung cancer after curative surgery

Yong Hoon Lee, Sook Kyung Do, Shin Yup Lee, Hyo Gyoung Kang, Jin Eun Choi, Mi Jeong Hong, Jang Hyuck Lee, Eung Bae Lee, Ji Yun Jeong, Kyung Min Shin, Won Kee Lee, Yangki Seok, Sukki Cho, Seung Soo Yoo, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, Sanghoon Jheon, Jae Yong Park

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

This study was conducted to investigate the associations between polymorphisms of genes involved in the LKB1 pathway and the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Twenty-three single nucleotide polymorphisms (SNPs) in the LKB1 pathway were investigated in 782 patients with NSCLC who underwent curative surgery. The association of SNPs with overall survival (OS) and disease-free survival (DFS) were analyzed. Among the 23 SNPs investigated, TSC2 rs30259G > A was associated with significantly worse OS and DFS (adjusted hazard ratio for OS 1.88, 95% confidence interval 1.21–2.91, P = 0.005; adjusted hazard ratio for DFS 1.65, 95% confidence interval 1.15–2.38, P = 0.01, under codominant models, respectively). Subgroup analysis showed that SNPs were significantly associated with survival outcomes in squamous cell carcinoma, ever-smokers, and stage I, but not in adenocarcinoma, never-smokers, and stage II–IIIA. The results suggest that TSC2 rs30259G > A may be useful to predict prognosis in patients with NSCLC, especially squamous cell carcinoma, after curative surgery.

Original languageEnglish
Pages (from-to)335-340
Number of pages6
JournalThoracic Cancer
Volume10
Issue number2
DOIs
StatePublished - Feb 2019

Keywords

  • Lung cancer
  • TSC2
  • polymorphism
  • prognosis

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