TSC2 genetic variant and prognosis in non-small cell lung cancer after curative surgery

Yong Hoon Lee; Sook Kyung Do; Shin Yup Lee; Hyo Gyoung Kang; Jin Eun Choi; Mi Jeong Hong; Jang Hyuck Lee; Eung Bae Lee; Ji Yun Jeong; Kyung Min Shin; Won Kee Lee; Yangki Seok; Sukki Cho; Seung Soo Yoo; Jaehee Lee; Seung Ick Cha; Chang Ho Kim; Sanghoon Jheon; Jae Yong Park

doi:10.1111/1759-7714.12951

TSC2 genetic variant and prognosis in non-small cell lung cancer after curative surgery

Yong Hoon Lee
, Sook Kyung Do
, Shin Yup Lee
, Hyo Gyoung Kang
, Jin Eun Choi
, Mi Jeong Hong
, Jang Hyuck Lee
, Eung Bae Lee
, Ji Yun Jeong
, Kyung Min Shin
, Won Kee Lee
, Yangki Seok
, Sukki Cho
, Seung Soo Yoo
, Jaehee Lee
, Seung Ick Cha
, Chang Ho Kim
, Sanghoon Jheon
, Jae Yong Park

Department of Medicine

Kyungpook National University
Soonchunhyang University
Seoul National University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

This study was conducted to investigate the associations between polymorphisms of genes involved in the LKB1 pathway and the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Twenty-three single nucleotide polymorphisms (SNPs) in the LKB1 pathway were investigated in 782 patients with NSCLC who underwent curative surgery. The association of SNPs with overall survival (OS) and disease-free survival (DFS) were analyzed. Among the 23 SNPs investigated, TSC2 rs30259G > A was associated with significantly worse OS and DFS (adjusted hazard ratio for OS 1.88, 95% confidence interval 1.21–2.91, P = 0.005; adjusted hazard ratio for DFS 1.65, 95% confidence interval 1.15–2.38, P = 0.01, under codominant models, respectively). Subgroup analysis showed that SNPs were significantly associated with survival outcomes in squamous cell carcinoma, ever-smokers, and stage I, but not in adenocarcinoma, never-smokers, and stage II–IIIA. The results suggest that TSC2 rs30259G > A may be useful to predict prognosis in patients with NSCLC, especially squamous cell carcinoma, after curative surgery.

Original language	English
Pages (from-to)	335-340
Number of pages	6
Journal	Thoracic Cancer
Volume	10
Issue number	2
DOIs	https://doi.org/10.1111/1759-7714.12951
State	Published - Feb 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Lung cancer
TSC2
polymorphism
prognosis

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10.1111/1759-7714.12951

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Lee, Y. H., Do, S. K., Lee, S. Y., Kang, H. G., Choi, J. E., Hong, M. J., Lee, J. H., Lee, E. B., Jeong, J. Y., Shin, K. M., Lee, W. K., Seok, Y., Cho, S., Yoo, S. S., Lee, J., Cha, S. I., Kim, C. H., Jheon, S., & Park, J. Y. (2019). TSC2 genetic variant and prognosis in non-small cell lung cancer after curative surgery. Thoracic Cancer, 10(2), 335-340. https://doi.org/10.1111/1759-7714.12951

@article{06ab6029c6414fd5a748769fc4e63a2d,

title = "TSC2 genetic variant and prognosis in non-small cell lung cancer after curative surgery",

abstract = "This study was conducted to investigate the associations between polymorphisms of genes involved in the LKB1 pathway and the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Twenty-three single nucleotide polymorphisms (SNPs) in the LKB1 pathway were investigated in 782 patients with NSCLC who underwent curative surgery. The association of SNPs with overall survival (OS) and disease-free survival (DFS) were analyzed. Among the 23 SNPs investigated, TSC2 rs30259G > A was associated with significantly worse OS and DFS (adjusted hazard ratio for OS 1.88, 95\% confidence interval 1.21–2.91, P = 0.005; adjusted hazard ratio for DFS 1.65, 95\% confidence interval 1.15–2.38, P = 0.01, under codominant models, respectively). Subgroup analysis showed that SNPs were significantly associated with survival outcomes in squamous cell carcinoma, ever-smokers, and stage I, but not in adenocarcinoma, never-smokers, and stage II–IIIA. The results suggest that TSC2 rs30259G > A may be useful to predict prognosis in patients with NSCLC, especially squamous cell carcinoma, after curative surgery.",

keywords = "Lung cancer, TSC2, polymorphism, prognosis",

author = "Lee, \{Yong Hoon\} and Do, \{Sook Kyung\} and Lee, \{Shin Yup\} and Kang, \{Hyo Gyoung\} and Choi, \{Jin Eun\} and Hong, \{Mi Jeong\} and Lee, \{Jang Hyuck\} and Lee, \{Eung Bae\} and Jeong, \{Ji Yun\} and Shin, \{Kyung Min\} and Lee, \{Won Kee\} and Yangki Seok and Sukki Cho and Yoo, \{Seung Soo\} and Jaehee Lee and Cha, \{Seung Ick\} and Kim, \{Chang Ho\} and Sanghoon Jheon and Park, \{Jae Yong\}",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley \& Sons Australia, Ltd",

year = "2019",

month = feb,

doi = "10.1111/1759-7714.12951",

language = "English",

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pages = "335--340",

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TY - JOUR

T1 - TSC2 genetic variant and prognosis in non-small cell lung cancer after curative surgery

AU - Lee, Yong Hoon

AU - Do, Sook Kyung

AU - Lee, Shin Yup

AU - Kang, Hyo Gyoung

AU - Choi, Jin Eun

AU - Hong, Mi Jeong

AU - Lee, Jang Hyuck

AU - Lee, Eung Bae

AU - Jeong, Ji Yun

AU - Shin, Kyung Min

AU - Lee, Won Kee

AU - Seok, Yangki

AU - Cho, Sukki

AU - Yoo, Seung Soo

AU - Lee, Jaehee

AU - Cha, Seung Ick

AU - Kim, Chang Ho

AU - Jheon, Sanghoon

AU - Park, Jae Yong

PY - 2019/2

Y1 - 2019/2

N2 - This study was conducted to investigate the associations between polymorphisms of genes involved in the LKB1 pathway and the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Twenty-three single nucleotide polymorphisms (SNPs) in the LKB1 pathway were investigated in 782 patients with NSCLC who underwent curative surgery. The association of SNPs with overall survival (OS) and disease-free survival (DFS) were analyzed. Among the 23 SNPs investigated, TSC2 rs30259G > A was associated with significantly worse OS and DFS (adjusted hazard ratio for OS 1.88, 95% confidence interval 1.21–2.91, P = 0.005; adjusted hazard ratio for DFS 1.65, 95% confidence interval 1.15–2.38, P = 0.01, under codominant models, respectively). Subgroup analysis showed that SNPs were significantly associated with survival outcomes in squamous cell carcinoma, ever-smokers, and stage I, but not in adenocarcinoma, never-smokers, and stage II–IIIA. The results suggest that TSC2 rs30259G > A may be useful to predict prognosis in patients with NSCLC, especially squamous cell carcinoma, after curative surgery.

AB - This study was conducted to investigate the associations between polymorphisms of genes involved in the LKB1 pathway and the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Twenty-three single nucleotide polymorphisms (SNPs) in the LKB1 pathway were investigated in 782 patients with NSCLC who underwent curative surgery. The association of SNPs with overall survival (OS) and disease-free survival (DFS) were analyzed. Among the 23 SNPs investigated, TSC2 rs30259G > A was associated with significantly worse OS and DFS (adjusted hazard ratio for OS 1.88, 95% confidence interval 1.21–2.91, P = 0.005; adjusted hazard ratio for DFS 1.65, 95% confidence interval 1.15–2.38, P = 0.01, under codominant models, respectively). Subgroup analysis showed that SNPs were significantly associated with survival outcomes in squamous cell carcinoma, ever-smokers, and stage I, but not in adenocarcinoma, never-smokers, and stage II–IIIA. The results suggest that TSC2 rs30259G > A may be useful to predict prognosis in patients with NSCLC, especially squamous cell carcinoma, after curative surgery.

KW - Lung cancer

KW - TSC2

KW - polymorphism

KW - prognosis

UR - https://www.scopus.com/pages/publications/85059067207

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DO - 10.1111/1759-7714.12951

M3 - Article

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AN - SCOPUS:85059067207

SN - 1759-7706

VL - 10

SP - 335

EP - 340

JO - Thoracic Cancer

JF - Thoracic Cancer

IS - 2

ER -

TSC2 genetic variant and prognosis in non-small cell lung cancer after curative surgery

Abstract

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Keywords

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