TWEAK Can Induce Pro-Inflammatory Cytokines and Matrix Metalloproteinase-9 in Macrophages

Se Hwa Kim; Yoon Joong Kang; Won Jung Kim; Dong Kyun Woo; Yoon Lee; Dong Ik Kim; Yong Bok Park; Byoung S. Kwon; Jeong Euy Park; Won Ha Lee

doi:10.1253/circj.68.396

TWEAK Can Induce Pro-Inflammatory Cytokines and Matrix Metalloproteinase-9 in Macrophages

Se Hwa Kim, Yoon Joong Kang, Won Jung Kim, Dong Kyun Woo, Yoon Lee, Dong Ik Kim, Yong Bok Park, Byoung S. Kwon, Jeong Euy Park, Won Ha Lee

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Abstract

The expression of TWEAK (TNFSF12) and TweakR/Fn14 was detected in regions rich in macrophage/foam cells in atherosclerotic plaques. The role of TWEAK in monocytes in relation to atherogenesis was investigated by analyzing the cellular events induced by TWEAK in a human macrophage-like cell line, THP-1. TWEAK induced various molecular mediators of atherogenesis, such as IL-6, MCP-1, IL-8 and MMP-9, and the induction was augmented by interferon-γ. TWEAK-induced activation of MMP-9 was mediated by activation of NF-κB. These results suggest that TWEAK is involved in atherosclerosis by inducing pro-inflammatory cytokines and extracellular matrix degrading enzymes, which reduce plaque stability.

Original language	English
Pages (from-to)	396-399
Number of pages	4
Journal	Circulation Journal
Volume	68
Issue number	4
DOIs	https://doi.org/10.1253/circj.68.396
State	Published - Apr 2004

Keywords

Atherosclerosis
Foam cells
TWEAK

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10.1253/circj.68.396

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title = "TWEAK Can Induce Pro-Inflammatory Cytokines and Matrix Metalloproteinase-9 in Macrophages",

abstract = "The expression of TWEAK (TNFSF12) and TweakR/Fn14 was detected in regions rich in macrophage/foam cells in atherosclerotic plaques. The role of TWEAK in monocytes in relation to atherogenesis was investigated by analyzing the cellular events induced by TWEAK in a human macrophage-like cell line, THP-1. TWEAK induced various molecular mediators of atherogenesis, such as IL-6, MCP-1, IL-8 and MMP-9, and the induction was augmented by interferon-γ. TWEAK-induced activation of MMP-9 was mediated by activation of NF-κB. These results suggest that TWEAK is involved in atherosclerosis by inducing pro-inflammatory cytokines and extracellular matrix degrading enzymes, which reduce plaque stability.",

keywords = "Atherosclerosis, Foam cells, TWEAK",

author = "Kim, {Se Hwa} and Kang, {Yoon Joong} and Kim, {Won Jung} and Woo, {Dong Kyun} and Yoon Lee and Kim, {Dong Ik} and Park, {Yong Bok} and Kwon, {Byoung S.} and Park, {Jeong Euy} and Lee, {Won Ha}",

year = "2004",

month = apr,

doi = "10.1253/circj.68.396",

language = "English",

volume = "68",

pages = "396--399",

journal = "Circulation Journal",

issn = "1346-9843",

publisher = "Japanese Circulation Society",

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T1 - TWEAK Can Induce Pro-Inflammatory Cytokines and Matrix Metalloproteinase-9 in Macrophages

AU - Kim, Se Hwa

AU - Kang, Yoon Joong

AU - Kim, Won Jung

AU - Woo, Dong Kyun

AU - Lee, Yoon

AU - Kim, Dong Ik

AU - Park, Yong Bok

AU - Kwon, Byoung S.

AU - Park, Jeong Euy

AU - Lee, Won Ha

PY - 2004/4

Y1 - 2004/4

N2 - The expression of TWEAK (TNFSF12) and TweakR/Fn14 was detected in regions rich in macrophage/foam cells in atherosclerotic plaques. The role of TWEAK in monocytes in relation to atherogenesis was investigated by analyzing the cellular events induced by TWEAK in a human macrophage-like cell line, THP-1. TWEAK induced various molecular mediators of atherogenesis, such as IL-6, MCP-1, IL-8 and MMP-9, and the induction was augmented by interferon-γ. TWEAK-induced activation of MMP-9 was mediated by activation of NF-κB. These results suggest that TWEAK is involved in atherosclerosis by inducing pro-inflammatory cytokines and extracellular matrix degrading enzymes, which reduce plaque stability.

AB - The expression of TWEAK (TNFSF12) and TweakR/Fn14 was detected in regions rich in macrophage/foam cells in atherosclerotic plaques. The role of TWEAK in monocytes in relation to atherogenesis was investigated by analyzing the cellular events induced by TWEAK in a human macrophage-like cell line, THP-1. TWEAK induced various molecular mediators of atherogenesis, such as IL-6, MCP-1, IL-8 and MMP-9, and the induction was augmented by interferon-γ. TWEAK-induced activation of MMP-9 was mediated by activation of NF-κB. These results suggest that TWEAK is involved in atherosclerosis by inducing pro-inflammatory cytokines and extracellular matrix degrading enzymes, which reduce plaque stability.

KW - Atherosclerosis

KW - Foam cells

KW - TWEAK

UR - http://www.scopus.com/inward/record.url?scp=11144353779&partnerID=8YFLogxK

U2 - 10.1253/circj.68.396

DO - 10.1253/circj.68.396

M3 - Article

C2 - 15056843

AN - SCOPUS:11144353779

SN - 1346-9843

VL - 68

SP - 396

EP - 399

JO - Circulation Journal

JF - Circulation Journal

IS - 4

ER -

TWEAK Can Induce Pro-Inflammatory Cytokines and Matrix Metalloproteinase-9 in Macrophages

Abstract

Keywords

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