Two distinct clones of carbapenem-resistant Acinetobacter baumannii isolates from Korean hospitals

Young Kyoung Park; Ji Young Choi; Sook In Jung; Kyong Hwa Park; Hyuck Lee; Dong Sik Jung; Sang Taek Heo; Shin Woo Kim; Hyun Ha Chang; Hae Suk Cheong; Doo Ryeon Chung; Kyong Ran Peck; Jae Hoon Song; Kwan Soo Ko

doi:10.1016/j.diagmicrobio.2009.03.029

Two distinct clones of carbapenem-resistant Acinetobacter baumannii isolates from Korean hospitals

Young Kyoung Park
, Ji Young Choi
, Sook In Jung
, Kyong Hwa Park
, Hyuck Lee
, Dong Sik Jung
, Sang Taek Heo
, Shin Woo Kim
, Hyun Ha Chang
, Hae Suk Cheong
, Doo Ryeon Chung
, Kyong Ran Peck
, Jae Hoon Song
, Kwan Soo Ko

Department of Medicine

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

We investigated the characteristics of 48 carbapenem-resistant Acinetobacter baumannii isolates collected from 5 tertiary care hospitals in Korea by multilocus sequencing typing, pulsed-field gel electrophoresis, and polymerase chain reaction amplification of the antimicrobial resistance determinants. We identified 2 distinct main clones of carbapenem-resistant A. baumannii isolates, which showed different antimicrobial resistance profiles and are also differentiated by the kinds of oxacillinase (OXA) carbapenemases and Acinetobacter-derived cephalosporinase (ADC) β-lactamases. One main clone, ST22:A, had 27 carbapenem-resistant isolates (56.3%), showed high polymyxin B and colistin resistances (33.3% and 37.0%, respectively), and contained both bla_OXA-51-like and bla_OXA-23-like genes and the bla_ADC-29 or bla_ADC-30 gene. In contrast, the other main clone, ST28:B, included 15 isolates (31.3%), showed complete susceptibilities to polymyxin B and colistin, and contained only the bla_OXA-51-like gene and bla_ADC-31 or bla_ADC-32 genes. The distribution of these main carbapenem-resistant A. baumannii clones did not relate to locality, indicating that they are widespread in Korean hospitals. In addition, we found new types of PER β-lactamases, PER-6.

Original language	English
Pages (from-to)	389-395
Number of pages	7
Journal	Diagnostic Microbiology and Infectious Disease
Volume	64
Issue number	4
DOIs	https://doi.org/10.1016/j.diagmicrobio.2009.03.029
State	Published - Aug 2009

Keywords

Acinetobacter baumannii
Carbapenemase
Colistin
Imipenem
Meropenem
Multilocus sequence typing (MLST)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diagmicrobio.2009.03.029

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Park, Y. K., Choi, J. Y., Jung, S. I., Park, K. H., Lee, H., Jung, D. S., Heo, S. T., Kim, S. W., Chang, H. H., Cheong, H. S., Chung, D. R., Peck, K. R., Song, J. H., & Ko, K. S. (2009). Two distinct clones of carbapenem-resistant Acinetobacter baumannii isolates from Korean hospitals. Diagnostic Microbiology and Infectious Disease, 64(4), 389-395. https://doi.org/10.1016/j.diagmicrobio.2009.03.029

@article{e028ff9697bd4cd690ec44f574e0ee7e,

title = "Two distinct clones of carbapenem-resistant Acinetobacter baumannii isolates from Korean hospitals",

abstract = "We investigated the characteristics of 48 carbapenem-resistant Acinetobacter baumannii isolates collected from 5 tertiary care hospitals in Korea by multilocus sequencing typing, pulsed-field gel electrophoresis, and polymerase chain reaction amplification of the antimicrobial resistance determinants. We identified 2 distinct main clones of carbapenem-resistant A. baumannii isolates, which showed different antimicrobial resistance profiles and are also differentiated by the kinds of oxacillinase (OXA) carbapenemases and Acinetobacter-derived cephalosporinase (ADC) β-lactamases. One main clone, ST22:A, had 27 carbapenem-resistant isolates (56.3\%), showed high polymyxin B and colistin resistances (33.3\% and 37.0\%, respectively), and contained both blaOXA-51-like and blaOXA-23-like genes and the blaADC-29 or blaADC-30 gene. In contrast, the other main clone, ST28:B, included 15 isolates (31.3\%), showed complete susceptibilities to polymyxin B and colistin, and contained only the blaOXA-51-like gene and blaADC-31 or blaADC-32 genes. The distribution of these main carbapenem-resistant A. baumannii clones did not relate to locality, indicating that they are widespread in Korean hospitals. In addition, we found new types of PER β-lactamases, PER-6.",

keywords = "Acinetobacter baumannii, Carbapenemase, Colistin, Imipenem, Meropenem, Multilocus sequence typing (MLST)",

author = "Park, \{Young Kyoung\} and Choi, \{Ji Young\} and Jung, \{Sook In\} and Park, \{Kyong Hwa\} and Hyuck Lee and Jung, \{Dong Sik\} and Heo, \{Sang Taek\} and Kim, \{Shin Woo\} and Chang, \{Hyun Ha\} and Cheong, \{Hae Suk\} and Chung, \{Doo Ryeon\} and Peck, \{Kyong Ran\} and Song, \{Jae Hoon\} and Ko, \{Kwan Soo\}",

year = "2009",

month = aug,

doi = "10.1016/j.diagmicrobio.2009.03.029",

language = "English",

volume = "64",

pages = "389--395",

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Park, YK, Choi, JY, Jung, SI, Park, KH, Lee, H, Jung, DS, Heo, ST, Kim, SW, Chang, HH, Cheong, HS, Chung, DR, Peck, KR, Song, JH & Ko, KS 2009, 'Two distinct clones of carbapenem-resistant Acinetobacter baumannii isolates from Korean hospitals', Diagnostic Microbiology and Infectious Disease, vol. 64, no. 4, pp. 389-395. https://doi.org/10.1016/j.diagmicrobio.2009.03.029

TY - JOUR

T1 - Two distinct clones of carbapenem-resistant Acinetobacter baumannii isolates from Korean hospitals

AU - Park, Young Kyoung

AU - Choi, Ji Young

AU - Jung, Sook In

AU - Park, Kyong Hwa

AU - Lee, Hyuck

AU - Jung, Dong Sik

AU - Heo, Sang Taek

AU - Kim, Shin Woo

AU - Chang, Hyun Ha

AU - Cheong, Hae Suk

AU - Chung, Doo Ryeon

AU - Peck, Kyong Ran

AU - Song, Jae Hoon

AU - Ko, Kwan Soo

PY - 2009/8

Y1 - 2009/8

N2 - We investigated the characteristics of 48 carbapenem-resistant Acinetobacter baumannii isolates collected from 5 tertiary care hospitals in Korea by multilocus sequencing typing, pulsed-field gel electrophoresis, and polymerase chain reaction amplification of the antimicrobial resistance determinants. We identified 2 distinct main clones of carbapenem-resistant A. baumannii isolates, which showed different antimicrobial resistance profiles and are also differentiated by the kinds of oxacillinase (OXA) carbapenemases and Acinetobacter-derived cephalosporinase (ADC) β-lactamases. One main clone, ST22:A, had 27 carbapenem-resistant isolates (56.3%), showed high polymyxin B and colistin resistances (33.3% and 37.0%, respectively), and contained both blaOXA-51-like and blaOXA-23-like genes and the blaADC-29 or blaADC-30 gene. In contrast, the other main clone, ST28:B, included 15 isolates (31.3%), showed complete susceptibilities to polymyxin B and colistin, and contained only the blaOXA-51-like gene and blaADC-31 or blaADC-32 genes. The distribution of these main carbapenem-resistant A. baumannii clones did not relate to locality, indicating that they are widespread in Korean hospitals. In addition, we found new types of PER β-lactamases, PER-6.

AB - We investigated the characteristics of 48 carbapenem-resistant Acinetobacter baumannii isolates collected from 5 tertiary care hospitals in Korea by multilocus sequencing typing, pulsed-field gel electrophoresis, and polymerase chain reaction amplification of the antimicrobial resistance determinants. We identified 2 distinct main clones of carbapenem-resistant A. baumannii isolates, which showed different antimicrobial resistance profiles and are also differentiated by the kinds of oxacillinase (OXA) carbapenemases and Acinetobacter-derived cephalosporinase (ADC) β-lactamases. One main clone, ST22:A, had 27 carbapenem-resistant isolates (56.3%), showed high polymyxin B and colistin resistances (33.3% and 37.0%, respectively), and contained both blaOXA-51-like and blaOXA-23-like genes and the blaADC-29 or blaADC-30 gene. In contrast, the other main clone, ST28:B, included 15 isolates (31.3%), showed complete susceptibilities to polymyxin B and colistin, and contained only the blaOXA-51-like gene and blaADC-31 or blaADC-32 genes. The distribution of these main carbapenem-resistant A. baumannii clones did not relate to locality, indicating that they are widespread in Korean hospitals. In addition, we found new types of PER β-lactamases, PER-6.

KW - Acinetobacter baumannii

KW - Carbapenemase

KW - Colistin

KW - Imipenem

KW - Meropenem

KW - Multilocus sequence typing (MLST)

UR - https://www.scopus.com/pages/publications/67650735380

U2 - 10.1016/j.diagmicrobio.2009.03.029

DO - 10.1016/j.diagmicrobio.2009.03.029

M3 - Article

C2 - 19631092

AN - SCOPUS:67650735380

SN - 0732-8893

VL - 64

SP - 389

EP - 395

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

IS - 4

ER -

Two distinct clones of carbapenem-resistant Acinetobacter baumannii isolates from Korean hospitals

Abstract

Keywords

UN SDGs

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