Two new cyototoxic cardenolides from the whole plants of Adonis multiflora Nishikawa & Koki Ito

Jae Woo Jung; Nam In Baek; Jeon Hwang-Bo; Seung Su Lee; Ji Hae Park; Kyeong Hwa Seo; Jung Hwa Kwon; Eun Ji Oh; Dae Young Lee; In Sik Chung; Myun Ho Bang

doi:10.3390/molecules201119722

Two new cyototoxic cardenolides from the whole plants of Adonis multiflora Nishikawa & Koki Ito

Jae Woo Jung, Nam In Baek, Jeon Hwang-Bo, Seung Su Lee, Ji Hae Park, Kyeong Hwa Seo, Jung Hwa Kwon, Eun Ji Oh, Dae Young Lee, In Sik Chung, Myun Ho Bang

School of Life Science and Biotechnology

Kyung Hee University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides-adonioside A (1) and adonioside B (6)-as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3).

Original language	English
Pages (from-to)	20823-20831
Number of pages	9
Journal	Molecules
Volume	20
Issue number	11
DOIs	https://doi.org/10.3390/molecules201119722
State	Published - 23 Nov 2015

Keywords

Adonioside A
Adonioside B
Adonis multiflora
Cardenolide
Cytotoxic activity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/molecules201119722

Cite this

@article{5cb8ece87da749c5ad55a7cd9b19e6c6,

title = "Two new cyototoxic cardenolides from the whole plants of Adonis multiflora Nishikawa & Koki Ito",

abstract = "A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides-adonioside A (1) and adonioside B (6)-as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3).",

keywords = "Adonioside A, Adonioside B, Adonis multiflora, Cardenolide, Cytotoxic activity",

author = "Jung, {Jae Woo} and Baek, {Nam In} and Jeon Hwang-Bo and Lee, {Seung Su} and Park, {Ji Hae} and Seo, {Kyeong Hwa} and Kwon, {Jung Hwa} and Oh, {Eun Ji} and Lee, {Dae Young} and Chung, {In Sik} and Bang, {Myun Ho}",

note = "Publisher Copyright: {\textcopyright} 2015 by The Authors.",

year = "2015",

month = nov,

day = "23",

doi = "10.3390/molecules201119722",

language = "English",

volume = "20",

pages = "20823--20831",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "11",

}

TY - JOUR

T1 - Two new cyototoxic cardenolides from the whole plants of Adonis multiflora Nishikawa & Koki Ito

AU - Jung, Jae Woo

AU - Baek, Nam In

AU - Hwang-Bo, Jeon

AU - Lee, Seung Su

AU - Park, Ji Hae

AU - Seo, Kyeong Hwa

AU - Kwon, Jung Hwa

AU - Oh, Eun Ji

AU - Lee, Dae Young

AU - Chung, In Sik

AU - Bang, Myun Ho

PY - 2015/11/23

Y1 - 2015/11/23

N2 - A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides-adonioside A (1) and adonioside B (6)-as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3).

AB - A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides-adonioside A (1) and adonioside B (6)-as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3).

KW - Adonioside A

KW - Adonioside B

KW - Adonis multiflora

KW - Cardenolide

KW - Cytotoxic activity

UR - http://www.scopus.com/inward/record.url?scp=84949968519&partnerID=8YFLogxK

U2 - 10.3390/molecules201119722

DO - 10.3390/molecules201119722

M3 - Article

C2 - 26610451

AN - SCOPUS:84949968519

SN - 1420-3049

VL - 20

SP - 20823

EP - 20831

JO - Molecules

JF - Molecules

IS - 11

ER -

Two new cyototoxic cardenolides from the whole plants of Adonis multiflora Nishikawa & Koki Ito

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this