Two new cyototoxic cardenolides from the whole plants of Adonis multiflora Nishikawa & Koki Ito

Jae Woo Jung; Nam In Baek; Jeon Hwang-Bo; Seung Su Lee; Ji Hae Park; Kyeong Hwa Seo; Jung Hwa Kwon; Eun Ji Oh; Dae Young Lee; In Sik Chung; Myun Ho Bang

doi:10.3390/molecules201119722

Two new cyototoxic cardenolides from the whole plants of Adonis multiflora Nishikawa & Koki Ito

Jae Woo Jung
, Nam In Baek
, Jeon Hwang-Bo
, Seung Su Lee
, Ji Hae Park
, Kyeong Hwa Seo
, Jung Hwa Kwon
, Eun Ji Oh
, Dae Young Lee
, In Sik Chung
, Myun Ho Bang

School of Life Science and Biotechnology

Kyung Hee University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides-adonioside A (1) and adonioside B (6)-as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3).

Original language	English
Pages (from-to)	20823-20831
Number of pages	9
Journal	Molecules
Volume	20
Issue number	11
DOIs	https://doi.org/10.3390/molecules201119722
State	Published - 23 Nov 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adonioside A
Adonioside B
Adonis multiflora
Cardenolide
Cytotoxic activity

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10.3390/molecules201119722

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title = "Two new cyototoxic cardenolides from the whole plants of Adonis multiflora Nishikawa \& Koki Ito",

abstract = "A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa \& Koki Ito. resulted in the isolation and identification of two new cardenolides-adonioside A (1) and adonioside B (6)-as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3).",

keywords = "Adonioside A, Adonioside B, Adonis multiflora, Cardenolide, Cytotoxic activity",

author = "Jung, \{Jae Woo\} and Baek, \{Nam In\} and Jeon Hwang-Bo and Lee, \{Seung Su\} and Park, \{Ji Hae\} and Seo, \{Kyeong Hwa\} and Kwon, \{Jung Hwa\} and Oh, \{Eun Ji\} and Lee, \{Dae Young\} and Chung, \{In Sik\} and Bang, \{Myun Ho\}",

note = "Publisher Copyright: {\textcopyright} 2015 by The Authors.",

year = "2015",

month = nov,

day = "23",

doi = "10.3390/molecules201119722",

language = "English",

volume = "20",

pages = "20823--20831",

journal = "Molecules",

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TY - JOUR

T1 - Two new cyototoxic cardenolides from the whole plants of Adonis multiflora Nishikawa & Koki Ito

AU - Jung, Jae Woo

AU - Baek, Nam In

AU - Hwang-Bo, Jeon

AU - Lee, Seung Su

AU - Park, Ji Hae

AU - Seo, Kyeong Hwa

AU - Kwon, Jung Hwa

AU - Oh, Eun Ji

AU - Lee, Dae Young

AU - Chung, In Sik

AU - Bang, Myun Ho

PY - 2015/11/23

Y1 - 2015/11/23

N2 - A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides-adonioside A (1) and adonioside B (6)-as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3).

AB - A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides-adonioside A (1) and adonioside B (6)-as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3).

KW - Adonioside A

KW - Adonioside B

KW - Adonis multiflora

KW - Cardenolide

KW - Cytotoxic activity

UR - https://www.scopus.com/pages/publications/84949968519

U2 - 10.3390/molecules201119722

DO - 10.3390/molecules201119722

M3 - Article

C2 - 26610451

AN - SCOPUS:84949968519

SN - 1420-3049

VL - 20

SP - 20823

EP - 20831

JO - Molecules

JF - Molecules

IS - 11

ER -

Two new cyototoxic cardenolides from the whole plants of Adonis multiflora Nishikawa & Koki Ito

Abstract

UN SDGs

Keywords

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