Tyrosinase inhibitors isolated from the roots of Glycyrrhiza glabra L.

Joo Sang Lee; Jeong Ah Kim; Se Hoon Cho; Ae Ryang Son; Tae Soo Jang; Myung Suk So; See Ryun Chung; Seung Ho Lee

Tyrosinase inhibitors isolated from the roots of Glycyrrhiza glabra L.

Joo Sang Lee
, Jeong Ah Kim
, Se Hoon Cho
, Ae Ryang Son
, Tae Soo Jang
, Myung Suk So
, See Ryun Chung
, Seung Ho Lee

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Eight compounds were isolated from the roots of Glycyrrhiza glabra by the tyrosinase inhibitory activity guided fractionation, and their structures were identified as liquiritigenin (1), isoliquiritigenin (2), isoliquiritigenin-2-O-methyl ether (3), liquiritin (4), isoliquiritin (5), ononin (6), glycycoumarin (7), glycyrol (8) by analysis of spectral data. Compound 3 exhibited the most potent inhibitory effect on mushroom tyrosinase activity (IC₅₀, 47 M).

Original language	English
Pages (from-to)	33-39
Number of pages	7
Journal	Korean Journal of Pharmacognosy
Volume	34
Issue number	1
State	Published - Mar 2003

Keywords

Flavonoid
Glycyrrhiza glabra
Isoliquiritigenin-2-O-methyl ether
Melanin polymer
Tyrosinase

Cite this

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title = "Tyrosinase inhibitors isolated from the roots of Glycyrrhiza glabra L.",

abstract = "Eight compounds were isolated from the roots of Glycyrrhiza glabra by the tyrosinase inhibitory activity guided fractionation, and their structures were identified as liquiritigenin (1), isoliquiritigenin (2), isoliquiritigenin-2-O-methyl ether (3), liquiritin (4), isoliquiritin (5), ononin (6), glycycoumarin (7), glycyrol (8) by analysis of spectral data. Compound 3 exhibited the most potent inhibitory effect on mushroom tyrosinase activity (IC50, 47 M).",

keywords = "Flavonoid, Glycyrrhiza glabra, Isoliquiritigenin-2-O-methyl ether, Melanin polymer, Tyrosinase",

author = "Lee, \{Joo Sang\} and Kim, \{Jeong Ah\} and Cho, \{Se Hoon\} and Son, \{Ae Ryang\} and Jang, \{Tae Soo\} and So, \{Myung Suk\} and Chung, \{See Ryun\} and Lee, \{Seung Ho\}",

year = "2003",

month = mar,

language = "English",

volume = "34",

pages = "33--39",

journal = "Korean Journal of Pharmacognosy",

issn = "0253-3073",

publisher = "Korean Society of Pharmacognosy",

number = "1",

}

TY - JOUR

T1 - Tyrosinase inhibitors isolated from the roots of Glycyrrhiza glabra L.

AU - Lee, Joo Sang

AU - Kim, Jeong Ah

AU - Cho, Se Hoon

AU - Son, Ae Ryang

AU - Jang, Tae Soo

AU - So, Myung Suk

AU - Chung, See Ryun

AU - Lee, Seung Ho

PY - 2003/3

Y1 - 2003/3

N2 - Eight compounds were isolated from the roots of Glycyrrhiza glabra by the tyrosinase inhibitory activity guided fractionation, and their structures were identified as liquiritigenin (1), isoliquiritigenin (2), isoliquiritigenin-2-O-methyl ether (3), liquiritin (4), isoliquiritin (5), ononin (6), glycycoumarin (7), glycyrol (8) by analysis of spectral data. Compound 3 exhibited the most potent inhibitory effect on mushroom tyrosinase activity (IC50, 47 M).

AB - Eight compounds were isolated from the roots of Glycyrrhiza glabra by the tyrosinase inhibitory activity guided fractionation, and their structures were identified as liquiritigenin (1), isoliquiritigenin (2), isoliquiritigenin-2-O-methyl ether (3), liquiritin (4), isoliquiritin (5), ononin (6), glycycoumarin (7), glycyrol (8) by analysis of spectral data. Compound 3 exhibited the most potent inhibitory effect on mushroom tyrosinase activity (IC50, 47 M).

KW - Flavonoid

KW - Glycyrrhiza glabra

KW - Isoliquiritigenin-2-O-methyl ether

KW - Melanin polymer

KW - Tyrosinase

UR - https://www.scopus.com/pages/publications/0037359622

M3 - Article

AN - SCOPUS:0037359622

SN - 0253-3073

VL - 34

SP - 33

EP - 39

JO - Korean Journal of Pharmacognosy

JF - Korean Journal of Pharmacognosy

IS - 1

ER -

Tyrosinase inhibitors isolated from the roots of Glycyrrhiza glabra L.

Abstract

Keywords

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