Tyrosinase inhibitory components from Aloe vera and their antiviral activity

Jang Hoon Kim; Ju Yeon Yoon; Seo Young Yang; Seung Kook Choi; Sun Jung Kwon; In Sook Cho; Min Hee Jeong; Young Ho Kim; Gug Seoun Choi

doi:10.1080/14756366.2016.1235568

Tyrosinase inhibitory components from Aloe vera and their antiviral activity

Jang Hoon Kim, Ju Yeon Yoon, Seo Young Yang, Seung Kook Choi, Sun Jung Kwon, In Sook Cho, Min Hee Jeong, Young Ho Kim, Gug Seoun Choi

Department of Biology Education

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2–9) were isolated from Aloe vera. Their structures were elucidated using 1D/2D nuclear magnetic resonance and mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC₅₀ value of 9.8 ± 0.9 µM. A molecular simulation revealed that compound 9 interacts via hydrogen bonding with residues His244, Thr261, and Val283 of tyrosinase. Additionally, compounds 3 and 7 were shown by half-leaf assays to exhibit inhibitory activity towards Pepper mild mottle virus.

Original language	English
Pages (from-to)	78-83
Number of pages	6
Journal	Journal of Enzyme Inhibition and Medicinal Chemistry
Volume	32
Issue number	1
DOIs	https://doi.org/10.1080/14756366.2016.1235568
State	Published - 1 Jan 2017

Keywords

Aloe vera
molecular docking
Pepper mild mottle virus
tyrosinase
Xanthorrhoeaceae

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10.1080/14756366.2016.1235568

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title = "Tyrosinase inhibitory components from Aloe vera and their antiviral activity",

abstract = "A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2–9) were isolated from Aloe vera. Their structures were elucidated using 1D/2D nuclear magnetic resonance and mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC50 value of 9.8 ± 0.9 µM. A molecular simulation revealed that compound 9 interacts via hydrogen bonding with residues His244, Thr261, and Val283 of tyrosinase. Additionally, compounds 3 and 7 were shown by half-leaf assays to exhibit inhibitory activity towards Pepper mild mottle virus.",

keywords = "Aloe vera, molecular docking, Pepper mild mottle virus, tyrosinase, Xanthorrhoeaceae",

author = "Kim, {Jang Hoon} and Yoon, {Ju Yeon} and Yang, {Seo Young} and Choi, {Seung Kook} and Kwon, {Sun Jung} and Cho, {In Sook} and Jeong, {Min Hee} and {Ho Kim}, Young and Choi, {Gug Seoun}",

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doi = "10.1080/14756366.2016.1235568",

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T1 - Tyrosinase inhibitory components from Aloe vera and their antiviral activity

AU - Kim, Jang Hoon

AU - Yoon, Ju Yeon

AU - Yang, Seo Young

AU - Choi, Seung Kook

AU - Kwon, Sun Jung

AU - Cho, In Sook

AU - Jeong, Min Hee

AU - Ho Kim, Young

AU - Choi, Gug Seoun

PY - 2017/1/1

Y1 - 2017/1/1

N2 - A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2–9) were isolated from Aloe vera. Their structures were elucidated using 1D/2D nuclear magnetic resonance and mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC50 value of 9.8 ± 0.9 µM. A molecular simulation revealed that compound 9 interacts via hydrogen bonding with residues His244, Thr261, and Val283 of tyrosinase. Additionally, compounds 3 and 7 were shown by half-leaf assays to exhibit inhibitory activity towards Pepper mild mottle virus.

AB - A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2–9) were isolated from Aloe vera. Their structures were elucidated using 1D/2D nuclear magnetic resonance and mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC50 value of 9.8 ± 0.9 µM. A molecular simulation revealed that compound 9 interacts via hydrogen bonding with residues His244, Thr261, and Val283 of tyrosinase. Additionally, compounds 3 and 7 were shown by half-leaf assays to exhibit inhibitory activity towards Pepper mild mottle virus.

KW - Aloe vera

KW - molecular docking

KW - Pepper mild mottle virus

KW - tyrosinase

KW - Xanthorrhoeaceae

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SN - 1475-6366

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JO - Journal of Enzyme Inhibition and Medicinal Chemistry

JF - Journal of Enzyme Inhibition and Medicinal Chemistry

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Tyrosinase inhibitory components from Aloe vera and their antiviral activity

Abstract

Keywords

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