Tyrosinase inhibitory components from Aloe vera and their antiviral activity

Jang Hoon Kim; Ju Yeon Yoon; Seo Young Yang; Seung Kook Choi; Sun Jung Kwon; In Sook Cho; Min Hee Jeong; Young Ho Kim; Gug Seoun Choi

doi:10.1080/14756366.2016.1235568

Tyrosinase inhibitory components from Aloe vera and their antiviral activity

Jang Hoon Kim
, Ju Yeon Yoon
, Seo Young Yang
, Seung Kook Choi
, Sun Jung Kwon
, In Sook Cho
, Min Hee Jeong
, Young Ho Kim
, Gug Seoun Choi

Department of Biology Education

Rural Development Administration
Chungnam National University

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2–9) were isolated from Aloe vera. Their structures were elucidated using 1D/2D nuclear magnetic resonance and mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC₅₀ value of 9.8 ± 0.9 µM. A molecular simulation revealed that compound 9 interacts via hydrogen bonding with residues His244, Thr261, and Val283 of tyrosinase. Additionally, compounds 3 and 7 were shown by half-leaf assays to exhibit inhibitory activity towards Pepper mild mottle virus.

Original language	English
Pages (from-to)	78-83
Number of pages	6
Journal	Journal of Enzyme Inhibition and Medicinal Chemistry
Volume	32
Issue number	1
DOIs	https://doi.org/10.1080/14756366.2016.1235568
State	Published - 1 Jan 2017

Keywords

Aloe vera
molecular docking
Pepper mild mottle virus
tyrosinase
Xanthorrhoeaceae

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10.1080/14756366.2016.1235568

Cite this

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title = "Tyrosinase inhibitory components from Aloe vera and their antiviral activity",

abstract = "A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2–9) were isolated from Aloe vera. Their structures were elucidated using 1D/2D nuclear magnetic resonance and mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC50 value of 9.8 ± 0.9 µM. A molecular simulation revealed that compound 9 interacts via hydrogen bonding with residues His244, Thr261, and Val283 of tyrosinase. Additionally, compounds 3 and 7 were shown by half-leaf assays to exhibit inhibitory activity towards Pepper mild mottle virus.",

keywords = "Aloe vera, molecular docking, Pepper mild mottle virus, tyrosinase, Xanthorrhoeaceae",

author = "Kim, \{Jang Hoon\} and Yoon, \{Ju Yeon\} and Yang, \{Seo Young\} and Choi, \{Seung Kook\} and Kwon, \{Sun Jung\} and Cho, \{In Sook\} and Jeong, \{Min Hee\} and \{Ho Kim\}, Young and Choi, \{Gug Seoun\}",

note = "Publisher Copyright: {\textcopyright} 2016 The Author(s). Published by Informa UK Limited, trading as Taylor \& Francis Group.",

year = "2017",

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day = "1",

doi = "10.1080/14756366.2016.1235568",

language = "English",

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T1 - Tyrosinase inhibitory components from Aloe vera and their antiviral activity

AU - Kim, Jang Hoon

AU - Yoon, Ju Yeon

AU - Yang, Seo Young

AU - Choi, Seung Kook

AU - Kwon, Sun Jung

AU - Cho, In Sook

AU - Jeong, Min Hee

AU - Ho Kim, Young

AU - Choi, Gug Seoun

PY - 2017/1/1

Y1 - 2017/1/1

N2 - A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2–9) were isolated from Aloe vera. Their structures were elucidated using 1D/2D nuclear magnetic resonance and mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC50 value of 9.8 ± 0.9 µM. A molecular simulation revealed that compound 9 interacts via hydrogen bonding with residues His244, Thr261, and Val283 of tyrosinase. Additionally, compounds 3 and 7 were shown by half-leaf assays to exhibit inhibitory activity towards Pepper mild mottle virus.

AB - A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2–9) were isolated from Aloe vera. Their structures were elucidated using 1D/2D nuclear magnetic resonance and mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC50 value of 9.8 ± 0.9 µM. A molecular simulation revealed that compound 9 interacts via hydrogen bonding with residues His244, Thr261, and Val283 of tyrosinase. Additionally, compounds 3 and 7 were shown by half-leaf assays to exhibit inhibitory activity towards Pepper mild mottle virus.

KW - Aloe vera

KW - molecular docking

KW - Pepper mild mottle virus

KW - tyrosinase

KW - Xanthorrhoeaceae

UR - https://www.scopus.com/pages/publications/85015593123

U2 - 10.1080/14756366.2016.1235568

DO - 10.1080/14756366.2016.1235568

M3 - Article

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AN - SCOPUS:85015593123

SN - 1475-6366

VL - 32

SP - 78

EP - 83

JO - Journal of Enzyme Inhibition and Medicinal Chemistry

JF - Journal of Enzyme Inhibition and Medicinal Chemistry

IS - 1

ER -

Tyrosinase inhibitory components from Aloe vera and their antiviral activity

Abstract

Keywords

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