Upregulation of PBR mRNA expression in human neuroblastoma cells by flavonoids

Jeoung Hee Ha; Jae Tae Lee; Ihn ho Cho; Kyung Ah Chun; Gi Eun Park; Hyung Chul Choi; Kwang Youn Lee; Sang Hyun Kim; Kyoungho Suk; In Kyeom Kim; Maan Gee Lee

doi:10.1016/j.phymed.2005.11.004

Upregulation of PBR mRNA expression in human neuroblastoma cells by flavonoids

Jeoung Hee Ha, Jae Tae Lee, Ihn ho Cho, Kyung Ah Chun, Gi Eun Park, Hyung Chul Choi, Kwang Youn Lee, Sang Hyun Kim, Kyoungho Suk, In Kyeom Kim, Maan Gee Lee

Department of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

To investigate the putative mediation of peripheral benzodiazepine receptor (PBR) in the cytotoxicity of flavonoids, in this study, modulatory effects of several flavonoids on the lipid peroxide (LPO) production and PBR mRNA expression of human neuroblastoma cells were observed. Elevated levels of peroxidated products in cancer cells may activate pro-apoptotic and anti-proliferative signaling pathways. Treatment of 10^-6 M 4′-chlorodiazepam and PK 11195 ligands of the PBR for 6 days enhanced the generation of LPO of the human neuroblastoma cells. Several flavonoids, well-known cytotoxic substances, potentiated the enhancement of LPO production by PBR ligands. Treatment of 10^-6 M flavonoids for 6 days elevated the expression of PBR mRNA in cells. These findings indicate that the potential of flavonoids to induce apoptosis in cancer cells is strongly associated with their PBR-inducing properties, thereby providing a new mechanism by which polyphenolic compounds may exert their cancer-preventive and anti-neoplastic effects.

Original language	English
Pages (from-to)	232-235
Number of pages	4
Journal	Phytomedicine
Volume	14
Issue number	2-3
DOIs	https://doi.org/10.1016/j.phymed.2005.11.004
State	Published - 19 Feb 2007

Keywords

Cancer cells
Cytotoxicity
Flavonoids
Peripheral benzodiazepine receptor (PBR)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phymed.2005.11.004

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title = "Upregulation of PBR mRNA expression in human neuroblastoma cells by flavonoids",

abstract = "To investigate the putative mediation of peripheral benzodiazepine receptor (PBR) in the cytotoxicity of flavonoids, in this study, modulatory effects of several flavonoids on the lipid peroxide (LPO) production and PBR mRNA expression of human neuroblastoma cells were observed. Elevated levels of peroxidated products in cancer cells may activate pro-apoptotic and anti-proliferative signaling pathways. Treatment of 10-6 M 4′-chlorodiazepam and PK 11195 ligands of the PBR for 6 days enhanced the generation of LPO of the human neuroblastoma cells. Several flavonoids, well-known cytotoxic substances, potentiated the enhancement of LPO production by PBR ligands. Treatment of 10-6 M flavonoids for 6 days elevated the expression of PBR mRNA in cells. These findings indicate that the potential of flavonoids to induce apoptosis in cancer cells is strongly associated with their PBR-inducing properties, thereby providing a new mechanism by which polyphenolic compounds may exert their cancer-preventive and anti-neoplastic effects.",

keywords = "Cancer cells, Cytotoxicity, Flavonoids, Peripheral benzodiazepine receptor (PBR)",

author = "Ha, {Jeoung Hee} and Lee, {Jae Tae} and Cho, {Ihn ho} and Chun, {Kyung Ah} and Park, {Gi Eun} and Choi, {Hyung Chul} and Lee, {Kwang Youn} and Kim, {Sang Hyun} and Kyoungho Suk and Kim, {In Kyeom} and Lee, {Maan Gee}",

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doi = "10.1016/j.phymed.2005.11.004",

language = "English",

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T1 - Upregulation of PBR mRNA expression in human neuroblastoma cells by flavonoids

AU - Ha, Jeoung Hee

AU - Lee, Jae Tae

AU - Cho, Ihn ho

AU - Chun, Kyung Ah

AU - Park, Gi Eun

AU - Choi, Hyung Chul

AU - Lee, Kwang Youn

AU - Kim, Sang Hyun

AU - Suk, Kyoungho

AU - Kim, In Kyeom

AU - Lee, Maan Gee

PY - 2007/2/19

Y1 - 2007/2/19

N2 - To investigate the putative mediation of peripheral benzodiazepine receptor (PBR) in the cytotoxicity of flavonoids, in this study, modulatory effects of several flavonoids on the lipid peroxide (LPO) production and PBR mRNA expression of human neuroblastoma cells were observed. Elevated levels of peroxidated products in cancer cells may activate pro-apoptotic and anti-proliferative signaling pathways. Treatment of 10-6 M 4′-chlorodiazepam and PK 11195 ligands of the PBR for 6 days enhanced the generation of LPO of the human neuroblastoma cells. Several flavonoids, well-known cytotoxic substances, potentiated the enhancement of LPO production by PBR ligands. Treatment of 10-6 M flavonoids for 6 days elevated the expression of PBR mRNA in cells. These findings indicate that the potential of flavonoids to induce apoptosis in cancer cells is strongly associated with their PBR-inducing properties, thereby providing a new mechanism by which polyphenolic compounds may exert their cancer-preventive and anti-neoplastic effects.

AB - To investigate the putative mediation of peripheral benzodiazepine receptor (PBR) in the cytotoxicity of flavonoids, in this study, modulatory effects of several flavonoids on the lipid peroxide (LPO) production and PBR mRNA expression of human neuroblastoma cells were observed. Elevated levels of peroxidated products in cancer cells may activate pro-apoptotic and anti-proliferative signaling pathways. Treatment of 10-6 M 4′-chlorodiazepam and PK 11195 ligands of the PBR for 6 days enhanced the generation of LPO of the human neuroblastoma cells. Several flavonoids, well-known cytotoxic substances, potentiated the enhancement of LPO production by PBR ligands. Treatment of 10-6 M flavonoids for 6 days elevated the expression of PBR mRNA in cells. These findings indicate that the potential of flavonoids to induce apoptosis in cancer cells is strongly associated with their PBR-inducing properties, thereby providing a new mechanism by which polyphenolic compounds may exert their cancer-preventive and anti-neoplastic effects.

KW - Cancer cells

KW - Cytotoxicity

KW - Flavonoids

KW - Peripheral benzodiazepine receptor (PBR)

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EP - 235

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ER -

Upregulation of PBR mRNA expression in human neuroblastoma cells by flavonoids

Abstract

Keywords

UN SDGs

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