TY - JOUR
T1 - Upregulation of Renal Water Channels and Sodium Transporters in Response to Ovariectomy in Rats
AU - Sardeli, C.
AU - Kwon, T. H.
AU - Li, C.
AU - Knepper, M. A.
AU - Nielsen, S.
AU - Frøkiær, J.
PY - 2004
Y1 - 2004
N2 - We report a highly significant increase in the expression levels of AQP2, -3, -1 and Na,K-ATPase in response to ovariectomy in rats. These findings were associated with increased levels of vasopressin 14 days after ovariectomy. Moreover, ovariectomy resulted in significant decrease in urine output and significant increase in body weight, suggesting that the functional impact of the AQP2, -3, -1 and Na,K-ATPase upregulation is water retention. Overall, the results of the present study support the view that female sex hormones play an important role in regulating renal water and sodium handling, through the regulation of AQPs.
AB - We report a highly significant increase in the expression levels of AQP2, -3, -1 and Na,K-ATPase in response to ovariectomy in rats. These findings were associated with increased levels of vasopressin 14 days after ovariectomy. Moreover, ovariectomy resulted in significant decrease in urine output and significant increase in body weight, suggesting that the functional impact of the AQP2, -3, -1 and Na,K-ATPase upregulation is water retention. Overall, the results of the present study support the view that female sex hormones play an important role in regulating renal water and sodium handling, through the regulation of AQPs.
UR - https://www.scopus.com/pages/publications/1542379808
M3 - Article
AN - SCOPUS:1542379808
SN - 1011-6583
VL - 18
SP - 167
EP - 169
JO - Review of Clinical Pharmacology and Pharmacokinetics, International Edition
JF - Review of Clinical Pharmacology and Pharmacokinetics, International Edition
IS - 1
ER -