Validation of the Bipolar Prodrome Symptom Interview and Scale-Abbreviated Prospective (BPSS-AP) in a clinical sample and healthy controls

Junhee Lee, Christoph U. Correll, Tae Young Lee, Sanghoon Oh, Jayoun Kim, Sang Jin Rhee, Minah Kim, Se Hyun Kim, Yong Min Ahn, Kyooseob Ha, Jun Soo Kwon

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: After the existence of a bipolar disorder (BD) prodrome was established, the development of clinical rating instruments has become relevant that are sufficiently brief to be implemented in real-world clinical practice and that are designed to identify individuals at-risk for BD. This study aimed to validate a shorter version of the Bipolar Prodrome Symptom Interview and Scale (BPSS), the BPSS-Abbreviated Prospective (BPSS-AP), for use among clinical populations. Methods: Altogether, 104 adults, comprising individuals diagnosed with BD (n = 17, mania: n = 8, hypomania: n = 9), with major depressive disorder (MDD, n = 38, all currently depressed), and healthy controls (HCs, n = 49), underwent BPSS-AP interviews. The psychometric properties of the BPSS-AP were evaluated, including internal consistency, convergent validity, discriminant validity, and factor structure. Results: The median (IQR) age was 29 (23–38), 40 (23–55), and 25 (22–28) years, for the BD, MDD, and HC groups, respectively. The BPSS-AP showed excellent internal consistency (Cronbach's α = 0.95). Convergent validity between the BPSS-AP and Young Mania Rating Scale (YMRS) was high (r > 0.7). The BPSS-AP discriminated patients with BD from those with MDD (P <.001) and from HCs (P <.001). Limitations: The study design precludes assessment of the predictive validity of the BPSS-AP. Conclusions: This study found that the BPSS-AP, a more concise and feasible version of the semi-structured interview for identifying individuals at risk of developing BD, has satisfactory psychometric properties. There is room for further validation and application of the BPSS-AP in clinical settings to evaluate its utility in research and clinical care.

Original languageEnglish
Pages (from-to)463-468
Number of pages6
JournalJournal of Affective Disorders
Volume324
DOIs
StatePublished - 1 Mar 2023

Keywords

  • Bipolar disorder
  • Prodromal symptoms
  • Psychiatric status rating scales

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