Various ligand-coated ultrasmall gadolinium-oxide nanoparticles: Water proton relaxivity and in-vivo T1 MR image

Ja Young Park; Sung June Kim; Gang Ho Lee; Seonguk Jin; Yongmin Chang; Ji Eun Bae; Kwon Seok Chae

doi:10.3938/jkps.66.1295

Various ligand-coated ultrasmall gadolinium-oxide nanoparticles: Water proton relaxivity and in-vivo T₁ MR image

Ja Young Park, Sung June Kim, Gang Ho Lee, Seonguk Jin, Yongmin Chang, Ji Eun Bae, Kwon Seok Chae

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Surface coating of nanoparticles with ligands is essential in magnetic resonance imaging (MRI) because of solubility in water and biocompatibility. In this study, five organic molecules were used for surface coating of ultrasmall gadolinium-oxide (Gd₂O₃) nanoparticles (d_avg = 2.0 nm). All of the samples showed large longitudinal (r₁) and transverse (r₂) water proton relaxivities with r₂/r₁ ratios that were close to one, corresponding to ideal conditions for T₁ MRI contrast agents. Finally, in-vivo T₁ MR images were acquired to prove the effectiveness of the surface-coated ultrasmall Gd₂O₃ nanoparticles as a T₁ MRI contrast agent.

Original language	English
Pages (from-to)	1295-1302
Number of pages	8
Journal	Journal of the Korean Physical Society
Volume	66
Issue number	8
DOIs	https://doi.org/10.3938/jkps.66.1295
State	Published - 1 Apr 2015

Keywords

Magnetic resonance imaging
Surface coating
Ultrasmall GdO nanoparticle
Water proton relaxivity

Access to Document

10.3938/jkps.66.1295

Cite this

@article{051bc74d62ed433398e3e2bc5d25c53a,

title = "Various ligand-coated ultrasmall gadolinium-oxide nanoparticles: Water proton relaxivity and in-vivo T1 MR image",

abstract = "Surface coating of nanoparticles with ligands is essential in magnetic resonance imaging (MRI) because of solubility in water and biocompatibility. In this study, five organic molecules were used for surface coating of ultrasmall gadolinium-oxide (Gd2O3) nanoparticles (davg = 2.0 nm). All of the samples showed large longitudinal (r1) and transverse (r2) water proton relaxivities with r2/r1 ratios that were close to one, corresponding to ideal conditions for T1 MRI contrast agents. Finally, in-vivo T1 MR images were acquired to prove the effectiveness of the surface-coated ultrasmall Gd2O3 nanoparticles as a T1 MRI contrast agent.",

keywords = "Magnetic resonance imaging, Surface coating, Ultrasmall GdO nanoparticle, Water proton relaxivity",

author = "Park, {Ja Young} and Kim, {Sung June} and Lee, {Gang Ho} and Seonguk Jin and Yongmin Chang and Bae, {Ji Eun} and Chae, {Kwon Seok}",

note = "Publisher Copyright: {\textcopyright} 2015, The Korean Physical Society.",

year = "2015",

month = apr,

day = "1",

doi = "10.3938/jkps.66.1295",

language = "English",

volume = "66",

pages = "1295--1302",

journal = "Journal of the Korean Physical Society",

issn = "0374-4884",

publisher = "Korean Physical Society",

number = "8",

}

TY - JOUR

T1 - Various ligand-coated ultrasmall gadolinium-oxide nanoparticles

T2 - Water proton relaxivity and in-vivo T1 MR image

AU - Park, Ja Young

AU - Kim, Sung June

AU - Lee, Gang Ho

AU - Jin, Seonguk

AU - Chang, Yongmin

AU - Bae, Ji Eun

AU - Chae, Kwon Seok

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Surface coating of nanoparticles with ligands is essential in magnetic resonance imaging (MRI) because of solubility in water and biocompatibility. In this study, five organic molecules were used for surface coating of ultrasmall gadolinium-oxide (Gd2O3) nanoparticles (davg = 2.0 nm). All of the samples showed large longitudinal (r1) and transverse (r2) water proton relaxivities with r2/r1 ratios that were close to one, corresponding to ideal conditions for T1 MRI contrast agents. Finally, in-vivo T1 MR images were acquired to prove the effectiveness of the surface-coated ultrasmall Gd2O3 nanoparticles as a T1 MRI contrast agent.

AB - Surface coating of nanoparticles with ligands is essential in magnetic resonance imaging (MRI) because of solubility in water and biocompatibility. In this study, five organic molecules were used for surface coating of ultrasmall gadolinium-oxide (Gd2O3) nanoparticles (davg = 2.0 nm). All of the samples showed large longitudinal (r1) and transverse (r2) water proton relaxivities with r2/r1 ratios that were close to one, corresponding to ideal conditions for T1 MRI contrast agents. Finally, in-vivo T1 MR images were acquired to prove the effectiveness of the surface-coated ultrasmall Gd2O3 nanoparticles as a T1 MRI contrast agent.

KW - Magnetic resonance imaging

KW - Surface coating

KW - Ultrasmall GdO nanoparticle

KW - Water proton relaxivity

UR - http://www.scopus.com/inward/record.url?scp=84946191866&partnerID=8YFLogxK

U2 - 10.3938/jkps.66.1295

DO - 10.3938/jkps.66.1295

M3 - Article

AN - SCOPUS:84946191866

SN - 0374-4884

VL - 66

SP - 1295

EP - 1302

JO - Journal of the Korean Physical Society

JF - Journal of the Korean Physical Society

IS - 8

ER -

Various ligand-coated ultrasmall gadolinium-oxide nanoparticles: Water proton relaxivity and in-vivo T₁ MR image

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this