Vascular barrier protective effects of eckol and its derivatives

Tae Hoon Kim; Taeho Lee; Sae Kwang Ku; Jong Sup Bae

doi:10.1016/j.bmcl.2012.04.026

Vascular barrier protective effects of eckol and its derivatives

Tae Hoon Kim
, Taeho Lee
, Sae Kwang Ku
, Jong Sup Bae

Daegu Haany University
Kyungpook National University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

In this Letter, we first investigated the barrier protective effects of eckol and its derivatives against pro-inflammatory responses in human umbilical vein endothelial cells (HUVECs) and in mice. Data showed that eckol (1) and dieckol (2) inhibited lipopolysaccharide (LPS)-mediated barrier disruption and transendothelial migration of leukocytes to human endothelial cells. Eckol (1) also suppressed acetic acid induced-hyperpermeability and carboxymethylcellulose-induced leukocytes migration in vivo. Interestingly, the barrier protective effects of dieckol (2) were better than those of eckol (1) and hydroxyl groups in dieckol (2) positively regulate protective effects.

Original language	English
Pages (from-to)	3710-3712
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	11
DOIs	https://doi.org/10.1016/j.bmcl.2012.04.026
State	Published - 1 Jun 2012

Keywords

Dieckol
Eckol
Endothelium
LPS
Vascular barrier integrity

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title = "Vascular barrier protective effects of eckol and its derivatives",

abstract = "In this Letter, we first investigated the barrier protective effects of eckol and its derivatives against pro-inflammatory responses in human umbilical vein endothelial cells (HUVECs) and in mice. Data showed that eckol (1) and dieckol (2) inhibited lipopolysaccharide (LPS)-mediated barrier disruption and transendothelial migration of leukocytes to human endothelial cells. Eckol (1) also suppressed acetic acid induced-hyperpermeability and carboxymethylcellulose-induced leukocytes migration in vivo. Interestingly, the barrier protective effects of dieckol (2) were better than those of eckol (1) and hydroxyl groups in dieckol (2) positively regulate protective effects.",

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T1 - Vascular barrier protective effects of eckol and its derivatives

AU - Hoon Kim, Tae

AU - Lee, Taeho

AU - Ku, Sae Kwang

AU - Bae, Jong Sup

PY - 2012/6/1

Y1 - 2012/6/1

N2 - In this Letter, we first investigated the barrier protective effects of eckol and its derivatives against pro-inflammatory responses in human umbilical vein endothelial cells (HUVECs) and in mice. Data showed that eckol (1) and dieckol (2) inhibited lipopolysaccharide (LPS)-mediated barrier disruption and transendothelial migration of leukocytes to human endothelial cells. Eckol (1) also suppressed acetic acid induced-hyperpermeability and carboxymethylcellulose-induced leukocytes migration in vivo. Interestingly, the barrier protective effects of dieckol (2) were better than those of eckol (1) and hydroxyl groups in dieckol (2) positively regulate protective effects.

AB - In this Letter, we first investigated the barrier protective effects of eckol and its derivatives against pro-inflammatory responses in human umbilical vein endothelial cells (HUVECs) and in mice. Data showed that eckol (1) and dieckol (2) inhibited lipopolysaccharide (LPS)-mediated barrier disruption and transendothelial migration of leukocytes to human endothelial cells. Eckol (1) also suppressed acetic acid induced-hyperpermeability and carboxymethylcellulose-induced leukocytes migration in vivo. Interestingly, the barrier protective effects of dieckol (2) were better than those of eckol (1) and hydroxyl groups in dieckol (2) positively regulate protective effects.

KW - Dieckol

KW - Eckol

KW - Endothelium

KW - LPS

KW - Vascular barrier integrity

UR - https://www.scopus.com/pages/publications/84861184505

U2 - 10.1016/j.bmcl.2012.04.026

DO - 10.1016/j.bmcl.2012.04.026

M3 - Article

C2 - 22543027

AN - SCOPUS:84861184505

SN - 0960-894X

VL - 22

SP - 3710

EP - 3712

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 11

ER -

Vascular barrier protective effects of eckol and its derivatives

Abstract

Keywords

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