TY - JOUR
T1 - Vasopressin stimulates the proliferation and differentiation of red blood cell precursors and improves recovery from anemia
AU - Mayer, Balázs
AU - Németh, Krisztián
AU - Krepuska, Miklós
AU - Myneni, Vamsee D.
AU - Maric, Dragan
AU - Tisdale, John F.
AU - Hsieh, Matthew M.
AU - Uchida, Naoya
AU - Lee, Heon Jin
AU - Nemeth, Michael J.
AU - Holmbeck, Kenn
AU - Noguchi, Constance Tom
AU - Rogers, Heather
AU - Dey, Soumyadeep
AU - Hansen, Arne
AU - Hong, Jeffrey
AU - Chow, Ian
AU - Key, Sharon
AU - Szalayova, Ildikó
AU - Pagani, Jerome
AU - Markó, Károly
AU - McClain-Caldwell, Ian
AU - Vitale-Cross, Lynn
AU - Young, W. Scott
AU - Brownstein, Michael J.
AU - Mezey, Éva
N1 - Publisher Copyright:
Copyright © 2017 The Authors, some rights reserved.
PY - 2017/11/29
Y1 - 2017/11/29
N2 - Arginine vasopressin (AVP) made by hypothalamic neurons is released into the circulation to stimulate water resorption by the kidneys and restore water balance after blood loss. Patients who lack this antidiuretic hormone suffer from central diabetes insipidus.We observed thatmany of these patients were anemic and asked whether AVP might play a role in red blood cell (RBC) production. We found that all three AVP receptors are expressed in human and mouse hematopoietic stem and progenitor cells. The AVPR1B appears to play the most important role in regulating erythropoiesis in both human and mouse cells. AVP increases phosphorylation of signal transducer and activator of transcription 5, as erythropoietin (EPO) does. After sublethal irradiation, AVP-deficient Brattleboro rats showed delayed recovery of RBC numbers compared to control rats. In mousemodels of anemia (induced by bleeding, irradiation, or increased destruction of circulating RBCs), AVP increased the number of circulating RBCs independently of EPO. In thesemodels, AVP appears to jump-start peripheral blood cell replenishment until EPO can take over. We suggest that specific AVPR1B agonistsmight be used to induce fast RBC production after bleeding, drug toxicity, or chemotherapy.
AB - Arginine vasopressin (AVP) made by hypothalamic neurons is released into the circulation to stimulate water resorption by the kidneys and restore water balance after blood loss. Patients who lack this antidiuretic hormone suffer from central diabetes insipidus.We observed thatmany of these patients were anemic and asked whether AVP might play a role in red blood cell (RBC) production. We found that all three AVP receptors are expressed in human and mouse hematopoietic stem and progenitor cells. The AVPR1B appears to play the most important role in regulating erythropoiesis in both human and mouse cells. AVP increases phosphorylation of signal transducer and activator of transcription 5, as erythropoietin (EPO) does. After sublethal irradiation, AVP-deficient Brattleboro rats showed delayed recovery of RBC numbers compared to control rats. In mousemodels of anemia (induced by bleeding, irradiation, or increased destruction of circulating RBCs), AVP increased the number of circulating RBCs independently of EPO. In thesemodels, AVP appears to jump-start peripheral blood cell replenishment until EPO can take over. We suggest that specific AVPR1B agonistsmight be used to induce fast RBC production after bleeding, drug toxicity, or chemotherapy.
UR - http://www.scopus.com/inward/record.url?scp=85036606295&partnerID=8YFLogxK
U2 - 10.1126/scitranslmed.aao1632
DO - 10.1126/scitranslmed.aao1632
M3 - Article
C2 - 29187641
AN - SCOPUS:85036606295
SN - 1946-6234
VL - 9
JO - Science Translational Medicine
JF - Science Translational Medicine
IS - 418
M1 - eaao1632
ER -