Vasopressin stimulates the proliferation and differentiation of red blood cell precursors and improves recovery from anemia

Balázs Mayer, Krisztián Németh, Miklós Krepuska, Vamsee D. Myneni, Dragan Maric, John F. Tisdale, Matthew M. Hsieh, Naoya Uchida, Heon Jin Lee, Michael J. Nemeth, Kenn Holmbeck, Constance Tom Noguchi, Heather Rogers, Soumyadeep Dey, Arne Hansen, Jeffrey Hong, Ian Chow, Sharon Key, Ildikó Szalayova, Jerome PaganiKároly Markó, Ian McClain-Caldwell, Lynn Vitale-Cross, W. Scott Young, Michael J. Brownstein, Éva Mezey

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Arginine vasopressin (AVP) made by hypothalamic neurons is released into the circulation to stimulate water resorption by the kidneys and restore water balance after blood loss. Patients who lack this antidiuretic hormone suffer from central diabetes insipidus.We observed thatmany of these patients were anemic and asked whether AVP might play a role in red blood cell (RBC) production. We found that all three AVP receptors are expressed in human and mouse hematopoietic stem and progenitor cells. The AVPR1B appears to play the most important role in regulating erythropoiesis in both human and mouse cells. AVP increases phosphorylation of signal transducer and activator of transcription 5, as erythropoietin (EPO) does. After sublethal irradiation, AVP-deficient Brattleboro rats showed delayed recovery of RBC numbers compared to control rats. In mousemodels of anemia (induced by bleeding, irradiation, or increased destruction of circulating RBCs), AVP increased the number of circulating RBCs independently of EPO. In thesemodels, AVP appears to jump-start peripheral blood cell replenishment until EPO can take over. We suggest that specific AVPR1B agonistsmight be used to induce fast RBC production after bleeding, drug toxicity, or chemotherapy.

Original languageEnglish
Article numbereaao1632
JournalScience Translational Medicine
Volume9
Issue number418
DOIs
StatePublished - 29 Nov 2017

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