Water-soluble D-glucuronic acid coated ultrasmall mixed Ln/Mn (Ln = Gd and Dy) oxide nanoparticles and their application to magnetic resonance imaging

Badrul Alam Bony; Jong Su Baeck; Yongmin Chang; Ji Eun Bae; Kwon Seok Chae; Gang Ho Lee

doi:10.1039/c4bm00107a

Water-soluble D-glucuronic acid coated ultrasmall mixed Ln/Mn (Ln = Gd and Dy) oxide nanoparticles and their application to magnetic resonance imaging

Badrul Alam Bony
, Jong Su Baeck
, Yongmin Chang
, Ji Eun Bae
, Kwon Seok Chae
, Gang Ho Lee

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Ultrasmall lanthanide oxide nanoparticles are promising materials as new magnetic resonance imaging (MRI) contrast agents because of their appreciable longitudinal (r₁) or transverse (r₂) water proton relaxivities at ultrasmall particle diameters. Two systems of d-glucuronic acid coated ultrasmall Ln/Mn (Ln = Gd and Dy) oxide nanoparticles with an average particle diameter of 2.0 nm were explored. The d-glucuronic acid coated ultrasmall Gd/Mn oxide nanoparticles showed strong positive contrast enhancements in 1.5 tesla T₁ MR images while the d-glucuronic acid coated ultrasmall Dy/Mn oxide nanoparticles showed appreciable negative contrast enhancements in 1.5 tesla T₂ MR images, proving their potential as T₁ and T₂ MRI contrast agents, respectively. This journal is

Original language	English
Pages (from-to)	1287-1295
Number of pages	9
Journal	Biomaterials Science
Volume	2
Issue number	9
DOIs	https://doi.org/10.1039/c4bm00107a
State	Published - Sep 2014

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10.1039/c4bm00107a

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title = "Water-soluble D-glucuronic acid coated ultrasmall mixed Ln/Mn (Ln = Gd and Dy) oxide nanoparticles and their application to magnetic resonance imaging",

abstract = "Ultrasmall lanthanide oxide nanoparticles are promising materials as new magnetic resonance imaging (MRI) contrast agents because of their appreciable longitudinal (r1) or transverse (r2) water proton relaxivities at ultrasmall particle diameters. Two systems of d-glucuronic acid coated ultrasmall Ln/Mn (Ln = Gd and Dy) oxide nanoparticles with an average particle diameter of 2.0 nm were explored. The d-glucuronic acid coated ultrasmall Gd/Mn oxide nanoparticles showed strong positive contrast enhancements in 1.5 tesla T1 MR images while the d-glucuronic acid coated ultrasmall Dy/Mn oxide nanoparticles showed appreciable negative contrast enhancements in 1.5 tesla T2 MR images, proving their potential as T1 and T2 MRI contrast agents, respectively. This journal is",

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doi = "10.1039/c4bm00107a",

language = "English",

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AU - Bony, Badrul Alam

AU - Baeck, Jong Su

AU - Chang, Yongmin

AU - Bae, Ji Eun

AU - Chae, Kwon Seok

AU - Lee, Gang Ho

PY - 2014/9

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AB - Ultrasmall lanthanide oxide nanoparticles are promising materials as new magnetic resonance imaging (MRI) contrast agents because of their appreciable longitudinal (r1) or transverse (r2) water proton relaxivities at ultrasmall particle diameters. Two systems of d-glucuronic acid coated ultrasmall Ln/Mn (Ln = Gd and Dy) oxide nanoparticles with an average particle diameter of 2.0 nm were explored. The d-glucuronic acid coated ultrasmall Gd/Mn oxide nanoparticles showed strong positive contrast enhancements in 1.5 tesla T1 MR images while the d-glucuronic acid coated ultrasmall Dy/Mn oxide nanoparticles showed appreciable negative contrast enhancements in 1.5 tesla T2 MR images, proving their potential as T1 and T2 MRI contrast agents, respectively. This journal is

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Water-soluble D-glucuronic acid coated ultrasmall mixed Ln/Mn (Ln = Gd and Dy) oxide nanoparticles and their application to magnetic resonance imaging

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