Water-soluble ultra-small manganese oxide surface doped gadolinium oxide (Gd2O3@MnO) nanoparticles for MRI contrast agent

Eun Sook Choi; Ja Young Park; Myung Ju Baek; Wenlong Xu; Krishna Kattel; Joo Hyun Kim; Jae Jun Lee; Yongmin Chang; Tae Jeong Kim; Ji Eun Bae; Kwon Seok Chae; Kyung Jin Suh; Gang Ho Lee

doi:10.1002/ejic.201000374

Water-soluble ultra-small manganese oxide surface doped gadolinium oxide (Gd₂O₃@MnO) nanoparticles for MRI contrast agent

Eun Sook Choi, Ja Young Park, Myung Ju Baek, Wenlong Xu, Krishna Kattel, Joo Hyun Kim, Jae Jun Lee, Yongmin Chang, Tae Jeong Kim, Ji Eun Bae, Kwon Seok Chae, Kyung Jin Suh, Gang Ho Lee

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Abstract

We have developed ultra-small gadolinium oxide (Gd₂O ₃) nanoparticles, which are surface-doped with manganese oxide (MnO) (abbreviated as Gd₂O₃@MnO). The surface-doped nanoparticles ranged from 1 to 2 nm in diameter. They were further coated with hydrophilic biocompatible lactobionic acid. In-vitro tests of the sample solution indicated clear dose-dependent contrast enhancements in both T ₁ and T₂ map images, showing that the nanoparticles may be used as both T₁ and T₂ MRI contrast agents. Their performance as a T1 MRI contrast agent was proved in vivo through T1 MR images of a mouse.

Original language	English
Pages (from-to)	4555-4560
Number of pages	6
Journal	European Journal of Inorganic Chemistry
Issue number	28
DOIs	https://doi.org/10.1002/ejic.201000374
State	Published - Oct 2010

Keywords

Colloids
Imaging agents
Nanoparticles
Nanotechnology

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10.1002/ejic.201000374

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Choi, E. S., Park, J. Y., Baek, M. J., Xu, W., Kattel, K., Kim, J. H., Lee, J. J., Chang, Y., Kim, T. J., Bae, J. E., Chae, K. S., Suh, K. J., & Lee, G. H. (2010). Water-soluble ultra-small manganese oxide surface doped gadolinium oxide (Gd₂O₃@MnO) nanoparticles for MRI contrast agent. European Journal of Inorganic Chemistry, (28), 4555-4560. https://doi.org/10.1002/ejic.201000374

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title = "Water-soluble ultra-small manganese oxide surface doped gadolinium oxide (Gd2O3@MnO) nanoparticles for MRI contrast agent",

abstract = "We have developed ultra-small gadolinium oxide (Gd2O 3) nanoparticles, which are surface-doped with manganese oxide (MnO) (abbreviated as Gd2O3@MnO). The surface-doped nanoparticles ranged from 1 to 2 nm in diameter. They were further coated with hydrophilic biocompatible lactobionic acid. In-vitro tests of the sample solution indicated clear dose-dependent contrast enhancements in both T 1 and T2 map images, showing that the nanoparticles may be used as both T1 and T2 MRI contrast agents. Their performance as a T1 MRI contrast agent was proved in vivo through T1 MR images of a mouse.",

keywords = "Colloids, Imaging agents, Nanoparticles, Nanotechnology",

author = "Choi, {Eun Sook} and Park, {Ja Young} and Baek, {Myung Ju} and Wenlong Xu and Krishna Kattel and Kim, {Joo Hyun} and Lee, {Jae Jun} and Yongmin Chang and Kim, {Tae Jeong} and Bae, {Ji Eun} and Chae, {Kwon Seok} and Suh, {Kyung Jin} and Lee, {Gang Ho}",

year = "2010",

month = oct,

doi = "10.1002/ejic.201000374",

language = "English",

pages = "4555--4560",

journal = "European Journal of Inorganic Chemistry",

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T1 - Water-soluble ultra-small manganese oxide surface doped gadolinium oxide (Gd2O3@MnO) nanoparticles for MRI contrast agent

AU - Choi, Eun Sook

AU - Park, Ja Young

AU - Baek, Myung Ju

AU - Xu, Wenlong

AU - Kattel, Krishna

AU - Kim, Joo Hyun

AU - Lee, Jae Jun

AU - Chang, Yongmin

AU - Kim, Tae Jeong

AU - Bae, Ji Eun

AU - Chae, Kwon Seok

AU - Suh, Kyung Jin

AU - Lee, Gang Ho

PY - 2010/10

Y1 - 2010/10

N2 - We have developed ultra-small gadolinium oxide (Gd2O 3) nanoparticles, which are surface-doped with manganese oxide (MnO) (abbreviated as Gd2O3@MnO). The surface-doped nanoparticles ranged from 1 to 2 nm in diameter. They were further coated with hydrophilic biocompatible lactobionic acid. In-vitro tests of the sample solution indicated clear dose-dependent contrast enhancements in both T 1 and T2 map images, showing that the nanoparticles may be used as both T1 and T2 MRI contrast agents. Their performance as a T1 MRI contrast agent was proved in vivo through T1 MR images of a mouse.

AB - We have developed ultra-small gadolinium oxide (Gd2O 3) nanoparticles, which are surface-doped with manganese oxide (MnO) (abbreviated as Gd2O3@MnO). The surface-doped nanoparticles ranged from 1 to 2 nm in diameter. They were further coated with hydrophilic biocompatible lactobionic acid. In-vitro tests of the sample solution indicated clear dose-dependent contrast enhancements in both T 1 and T2 map images, showing that the nanoparticles may be used as both T1 and T2 MRI contrast agents. Their performance as a T1 MRI contrast agent was proved in vivo through T1 MR images of a mouse.

KW - Colloids

KW - Imaging agents

KW - Nanoparticles

KW - Nanotechnology

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U2 - 10.1002/ejic.201000374

DO - 10.1002/ejic.201000374

M3 - Article

AN - SCOPUS:77957801272

SN - 1434-1948

SP - 4555

EP - 4560

JO - European Journal of Inorganic Chemistry

JF - European Journal of Inorganic Chemistry

IS - 28

ER -

Water-soluble ultra-small manganese oxide surface doped gadolinium oxide (Gd₂O₃@MnO) nanoparticles for MRI contrast agent

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