Water-soluble ultrasmall Eu2O3 nanoparticles as a fluorescent imaging agent: In vitro and in vivo studies

Krishna Kattel; Ja Young Park; Wenlong Xu; Han Gyeol Kim; Eun Jung Lee; Badrul Alam Bony; Woo Choul Heo; Yongmin Chang; Tae Jeong Kim; Ji Yeon Do; Kwon Seok Chae; Young Woo Kwak; Gang Ho Lee

doi:10.1016/j.colsurfa.2011.11.032

Water-soluble ultrasmall Eu₂O₃ nanoparticles as a fluorescent imaging agent: In vitro and in vivo studies

Krishna Kattel
, Ja Young Park
, Wenlong Xu
, Han Gyeol Kim
, Eun Jung Lee
, Badrul Alam Bony
, Woo Choul Heo
, Yongmin Chang
, Tae Jeong Kim
, Ji Yeon Do
, Kwon Seok Chae
, Young Woo Kwak
, Gang Ho Lee

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The water-soluble d-glucuronic acid coated ultrasmall Eu₂O₃ nanoparticles with particle diameters ranging from 1.0 to 3.0nm and with a hydrodynamic diameter of 4.71nm were synthesized in one-pot solution phase reaction and their fluorescent imaging properties were characterized in vitro and in vivo. They showed a strong fluorescence in the red region, a high photostability, a narrow bandwidth, and non-toxicity up to 0.5mM Eu, which is suitable for a high performance fluorescent imaging agent. This was proved in in vitro intracellular imaging of DU 145 cells and in vivo imaging of a digestive system of a small animal Caenorhabditis elegans.

Original language	English
Pages (from-to)	85-91
Number of pages	7
Journal	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volume	394
DOIs	https://doi.org/10.1016/j.colsurfa.2011.11.032
State	Published - 20 Jan 2012

Keywords

Fluorescent imaging agent
In vitro
In vivo

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10.1016/j.colsurfa.2011.11.032

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Kattel, K., Park, J. Y., Xu, W., Kim, H. G., Lee, E. J., Bony, B. A., Heo, W. C., Chang, Y., Kim, T. J., Do, J. Y., Chae, K. S., Kwak, Y. W., & Lee, G. H. (2012). Water-soluble ultrasmall Eu₂O₃ nanoparticles as a fluorescent imaging agent: In vitro and in vivo studies. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 394, 85-91. https://doi.org/10.1016/j.colsurfa.2011.11.032

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title = "Water-soluble ultrasmall Eu2O3 nanoparticles as a fluorescent imaging agent: In vitro and in vivo studies",

abstract = "The water-soluble d-glucuronic acid coated ultrasmall Eu2O3 nanoparticles with particle diameters ranging from 1.0 to 3.0nm and with a hydrodynamic diameter of 4.71nm were synthesized in one-pot solution phase reaction and their fluorescent imaging properties were characterized in vitro and in vivo. They showed a strong fluorescence in the red region, a high photostability, a narrow bandwidth, and non-toxicity up to 0.5mM Eu, which is suitable for a high performance fluorescent imaging agent. This was proved in in vitro intracellular imaging of DU 145 cells and in vivo imaging of a digestive system of a small animal Caenorhabditis elegans.",

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doi = "10.1016/j.colsurfa.2011.11.032",

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T2 - In vitro and in vivo studies

AU - Kattel, Krishna

AU - Park, Ja Young

AU - Xu, Wenlong

AU - Kim, Han Gyeol

AU - Lee, Eun Jung

AU - Bony, Badrul Alam

AU - Heo, Woo Choul

AU - Chang, Yongmin

AU - Kim, Tae Jeong

AU - Do, Ji Yeon

AU - Chae, Kwon Seok

AU - Kwak, Young Woo

AU - Lee, Gang Ho

PY - 2012/1/20

Y1 - 2012/1/20

N2 - The water-soluble d-glucuronic acid coated ultrasmall Eu2O3 nanoparticles with particle diameters ranging from 1.0 to 3.0nm and with a hydrodynamic diameter of 4.71nm were synthesized in one-pot solution phase reaction and their fluorescent imaging properties were characterized in vitro and in vivo. They showed a strong fluorescence in the red region, a high photostability, a narrow bandwidth, and non-toxicity up to 0.5mM Eu, which is suitable for a high performance fluorescent imaging agent. This was proved in in vitro intracellular imaging of DU 145 cells and in vivo imaging of a digestive system of a small animal Caenorhabditis elegans.

AB - The water-soluble d-glucuronic acid coated ultrasmall Eu2O3 nanoparticles with particle diameters ranging from 1.0 to 3.0nm and with a hydrodynamic diameter of 4.71nm were synthesized in one-pot solution phase reaction and their fluorescent imaging properties were characterized in vitro and in vivo. They showed a strong fluorescence in the red region, a high photostability, a narrow bandwidth, and non-toxicity up to 0.5mM Eu, which is suitable for a high performance fluorescent imaging agent. This was proved in in vitro intracellular imaging of DU 145 cells and in vivo imaging of a digestive system of a small animal Caenorhabditis elegans.

KW - Fluorescent imaging agent

KW - In vitro

KW - In vivo

UR - https://www.scopus.com/pages/publications/84855256701

U2 - 10.1016/j.colsurfa.2011.11.032

DO - 10.1016/j.colsurfa.2011.11.032

M3 - Article

AN - SCOPUS:84855256701

SN - 0927-7757

VL - 394

SP - 85

EP - 91

JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects

JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects

ER -

Water-soluble ultrasmall Eu₂O₃ nanoparticles as a fluorescent imaging agent: In vitro and in vivo studies

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Keywords

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