White ginseng extract induces immunomodulatory effects via the MKK4-JNK pathway

Tae Gyu Lim; Mi Jang; Chang Won Cho; Hee Do Hong; Kyung Tack Kim; Sung Young Lee; Sung Keun Jung; Young Kyoung Rhee

doi:10.1007/s10068-016-0265-6

White ginseng extract induces immunomodulatory effects via the MKK4-JNK pathway

Tae Gyu Lim, Mi Jang, Chang Won Cho, Hee Do Hong, Kyung Tack Kim, Sung Young Lee, Sung Keun Jung, Young Kyoung Rhee

School of Food Science & Biotechnology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Panax ginseng Meyer (white ginseng) is a popular functional food and its biological effects on the human body have been noted for hundreds of years. In the present study, the underlying mechanisms responsible for the immunomodulatory effects of white ginseng extract (WGE) were investigated. WGE increased NO production via upregulation of iNOS expression levels. Mouse cytokine array results also revealed that the expression of 13 cytokines was elevated by WGE treatment in IFN-γ-primed macrophage cells. Although both MKK4-JNK and MEK-ERK signaling pathways were activated after treatment with WGE, only the MKK4-JNK signaling pathway appears to have any significant immunomodulatory significance. Oral administration of WGE for 28 days recovered cyclophosphamide (CY)-induced suppression of the immune system in mice via the MKK4-JNK pathway. Taken together, these findings suggest that the MKK4-JNK signaling pathway is a crucial mechanism of WGE-induced immunomodulation.

Original language	English
Pages (from-to)	1737-1744
Number of pages	8
Journal	Food Science and Biotechnology
Volume	25
Issue number	6
DOIs	https://doi.org/10.1007/s10068-016-0265-6
State	Published - 1 Dec 2016

Keywords

JNK
MKK4
cytokines
immunomodulation
white ginseng extract

Access to Document

10.1007/s10068-016-0265-6

Cite this

@article{a68d39367d274812b101f28ea128aa8f,

title = "White ginseng extract induces immunomodulatory effects via the MKK4-JNK pathway",

abstract = "Panax ginseng Meyer (white ginseng) is a popular functional food and its biological effects on the human body have been noted for hundreds of years. In the present study, the underlying mechanisms responsible for the immunomodulatory effects of white ginseng extract (WGE) were investigated. WGE increased NO production via upregulation of iNOS expression levels. Mouse cytokine array results also revealed that the expression of 13 cytokines was elevated by WGE treatment in IFN-γ-primed macrophage cells. Although both MKK4-JNK and MEK-ERK signaling pathways were activated after treatment with WGE, only the MKK4-JNK signaling pathway appears to have any significant immunomodulatory significance. Oral administration of WGE for 28 days recovered cyclophosphamide (CY)-induced suppression of the immune system in mice via the MKK4-JNK pathway. Taken together, these findings suggest that the MKK4-JNK signaling pathway is a crucial mechanism of WGE-induced immunomodulation.",

keywords = "JNK, MKK4, cytokines, immunomodulation, white ginseng extract",

author = "Lim, {Tae Gyu} and Mi Jang and Cho, {Chang Won} and Hong, {Hee Do} and Kim, {Kyung Tack} and Lee, {Sung Young} and Jung, {Sung Keun} and Rhee, {Young Kyoung}",

note = "Publisher Copyright: {\textcopyright} 2016, The Korean Society of Food Science and Technology and Springer Science+Business Media Dordrecht.",

year = "2016",

month = dec,

day = "1",

doi = "10.1007/s10068-016-0265-6",

language = "English",

volume = "25",

pages = "1737--1744",

journal = "Food Science and Biotechnology",

issn = "1226-7708",

publisher = "Springer Netherlands",

number = "6",

}

TY - JOUR

T1 - White ginseng extract induces immunomodulatory effects via the MKK4-JNK pathway

AU - Lim, Tae Gyu

AU - Jang, Mi

AU - Cho, Chang Won

AU - Hong, Hee Do

AU - Kim, Kyung Tack

AU - Lee, Sung Young

AU - Jung, Sung Keun

AU - Rhee, Young Kyoung

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Panax ginseng Meyer (white ginseng) is a popular functional food and its biological effects on the human body have been noted for hundreds of years. In the present study, the underlying mechanisms responsible for the immunomodulatory effects of white ginseng extract (WGE) were investigated. WGE increased NO production via upregulation of iNOS expression levels. Mouse cytokine array results also revealed that the expression of 13 cytokines was elevated by WGE treatment in IFN-γ-primed macrophage cells. Although both MKK4-JNK and MEK-ERK signaling pathways were activated after treatment with WGE, only the MKK4-JNK signaling pathway appears to have any significant immunomodulatory significance. Oral administration of WGE for 28 days recovered cyclophosphamide (CY)-induced suppression of the immune system in mice via the MKK4-JNK pathway. Taken together, these findings suggest that the MKK4-JNK signaling pathway is a crucial mechanism of WGE-induced immunomodulation.

AB - Panax ginseng Meyer (white ginseng) is a popular functional food and its biological effects on the human body have been noted for hundreds of years. In the present study, the underlying mechanisms responsible for the immunomodulatory effects of white ginseng extract (WGE) were investigated. WGE increased NO production via upregulation of iNOS expression levels. Mouse cytokine array results also revealed that the expression of 13 cytokines was elevated by WGE treatment in IFN-γ-primed macrophage cells. Although both MKK4-JNK and MEK-ERK signaling pathways were activated after treatment with WGE, only the MKK4-JNK signaling pathway appears to have any significant immunomodulatory significance. Oral administration of WGE for 28 days recovered cyclophosphamide (CY)-induced suppression of the immune system in mice via the MKK4-JNK pathway. Taken together, these findings suggest that the MKK4-JNK signaling pathway is a crucial mechanism of WGE-induced immunomodulation.

KW - JNK

KW - MKK4

KW - cytokines

KW - immunomodulation

KW - white ginseng extract

UR - http://www.scopus.com/inward/record.url?scp=85008479953&partnerID=8YFLogxK

U2 - 10.1007/s10068-016-0265-6

DO - 10.1007/s10068-016-0265-6

M3 - Article

AN - SCOPUS:85008479953

SN - 1226-7708

VL - 25

SP - 1737

EP - 1744

JO - Food Science and Biotechnology

JF - Food Science and Biotechnology

IS - 6

ER -

White ginseng extract induces immunomodulatory effects via the MKK4-JNK pathway

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this