X-ray Attenuation Properties of Ultrasmall Yb 2 O 3 Nanoparticles as a High-Performance CT Contrast Agent

Adibehalsadat Ghazanfari, Shanti Marasini, Tirusew Tegafaw, Son Long Ho, Xu Miao, Mohammad Yaseen Ahmad, Huan Yue, Gang Ho Lee, Ji Ae Park, Ki Hye Jung, Yongmin Chang, In Taek Oh, Kwon Seok Chae

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Ultrasmall heavy metal-oxide nanoparticles can be utilized for highly enhancing contrasts in computed tomography (CT). In this study, ultrasmall Yb 2 O 3 nanoparticles coated with biocompatible and hydrophilic D-glucuronic acid were for the first time prepared through a simple one-step polyol process, and their X-ray attenuation properties were investigated by measuring phantom images and X-ray attenuation powers. The average particle diameter of the nanoparticles was estimated to be 2.1 ± 0.1 nm by using transmission electron microscopy. The observed X-ray attenuation power was stronger than that of a commercial iodine CT contrast agent (i.e., Ultravist®) at the same atomic concentration and much stronger at the same number density, proving the potential of ultrasmall Yb 2 O 3 nanoparticles for use as a powerful CT contrast agent.

Original languageEnglish
Pages (from-to)286-291
Number of pages6
JournalJournal of the Korean Physical Society
Volume74
Issue number3
DOIs
StatePublished - 1 Feb 2019

Keywords

  • CT contrast agent
  • Ultrasmall nanoparticle
  • Yb O

Fingerprint

Dive into the research topics of 'X-ray Attenuation Properties of Ultrasmall Yb 2 O 3 Nanoparticles as a High-Performance CT Contrast Agent'. Together they form a unique fingerprint.

Cite this