X-ray Attenuation Properties of Ultrasmall Yb                         2                         O                         3                          Nanoparticles as a High-Performance CT Contrast Agent

Adibehalsadat Ghazanfari; Shanti Marasini; Tirusew Tegafaw; Son Long Ho; Xu Miao; Mohammad Yaseen Ahmad; Huan Yue; Gang Ho Lee; Ji Ae Park; Ki Hye Jung; Yongmin Chang; In Taek Oh; Kwon Seok Chae

doi:10.3938/jkps.74.286

X-ray Attenuation Properties of Ultrasmall Yb ₂ O ₃ Nanoparticles as a High-Performance CT Contrast Agent

Adibehalsadat Ghazanfari, Shanti Marasini, Tirusew Tegafaw, Son Long Ho, Xu Miao, Mohammad Yaseen Ahmad, Huan Yue, Gang Ho Lee, Ji Ae Park, Ki Hye Jung, Yongmin Chang, In Taek Oh, Kwon Seok Chae

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Ultrasmall heavy metal-oxide nanoparticles can be utilized for highly enhancing contrasts in computed tomography (CT). In this study, ultrasmall Yb ₂ O ₃ nanoparticles coated with biocompatible and hydrophilic D-glucuronic acid were for the first time prepared through a simple one-step polyol process, and their X-ray attenuation properties were investigated by measuring phantom images and X-ray attenuation powers. The average particle diameter of the nanoparticles was estimated to be 2.1 ± 0.1 nm by using transmission electron microscopy. The observed X-ray attenuation power was stronger than that of a commercial iodine CT contrast agent (i.e., Ultravist®) at the same atomic concentration and much stronger at the same number density, proving the potential of ultrasmall Yb ₂ O ₃ nanoparticles for use as a powerful CT contrast agent.

Original language	English
Pages (from-to)	286-291
Number of pages	6
Journal	Journal of the Korean Physical Society
Volume	74
Issue number	3
DOIs	https://doi.org/10.3938/jkps.74.286
State	Published - 1 Feb 2019

Keywords

CT contrast agent
Ultrasmall nanoparticle
Yb O

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10.3938/jkps.74.286

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Ghazanfari, A., Marasini, S., Tegafaw, T., Ho, S. L., Miao, X., Ahmad, M. Y., Yue, H., Lee, G. H., Park, J. A., Jung, K. H., Chang, Y., Oh, I. T., & Chae, K. S. (2019). X-ray Attenuation Properties of Ultrasmall Yb ₂ O ₃ Nanoparticles as a High-Performance CT Contrast Agent Journal of the Korean Physical Society, 74(3), 286-291. https://doi.org/10.3938/jkps.74.286

Ghazanfari, Adibehalsadat ; Marasini, Shanti ; Tegafaw, Tirusew et al. / X-ray Attenuation Properties of Ultrasmall Yb ₂ O ₃ Nanoparticles as a High-Performance CT Contrast Agent In: Journal of the Korean Physical Society. 2019 ; Vol. 74, No. 3. pp. 286-291.

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title = " X-ray Attenuation Properties of Ultrasmall Yb 2 O 3 Nanoparticles as a High-Performance CT Contrast Agent ",

abstract = " Ultrasmall heavy metal-oxide nanoparticles can be utilized for highly enhancing contrasts in computed tomography (CT). In this study, ultrasmall Yb 2 O 3 nanoparticles coated with biocompatible and hydrophilic D-glucuronic acid were for the first time prepared through a simple one-step polyol process, and their X-ray attenuation properties were investigated by measuring phantom images and X-ray attenuation powers. The average particle diameter of the nanoparticles was estimated to be 2.1 ± 0.1 nm by using transmission electron microscopy. The observed X-ray attenuation power was stronger than that of a commercial iodine CT contrast agent (i.e., Ultravist{\textregistered}) at the same atomic concentration and much stronger at the same number density, proving the potential of ultrasmall Yb 2 O 3 nanoparticles for use as a powerful CT contrast agent.",

keywords = "CT contrast agent, Ultrasmall nanoparticle, Yb O",

author = "Adibehalsadat Ghazanfari and Shanti Marasini and Tirusew Tegafaw and Ho, \{Son Long\} and Xu Miao and Ahmad, \{Mohammad Yaseen\} and Huan Yue and Lee, \{Gang Ho\} and Park, \{Ji Ae\} and Jung, \{Ki Hye\} and Yongmin Chang and Oh, \{In Taek\} and Chae, \{Kwon Seok\}",

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year = "2019",

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doi = "10.3938/jkps.74.286",

language = "English",

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Ghazanfari, A, Marasini, S, Tegafaw, T, Ho, SL, Miao, X, Ahmad, MY, Yue, H, Lee, GH, Park, JA, Jung, KH, Chang, Y, Oh, IT & Chae, KS 2019, ' X-ray Attenuation Properties of Ultrasmall Yb ₂ O ₃ Nanoparticles as a High-Performance CT Contrast Agent ', Journal of the Korean Physical Society, vol. 74, no. 3, pp. 286-291. https://doi.org/10.3938/jkps.74.286

X-ray Attenuation Properties of Ultrasmall Yb ₂ O ₃ Nanoparticles as a High-Performance CT Contrast Agent . / Ghazanfari, Adibehalsadat; Marasini, Shanti; Tegafaw, Tirusew et al.
In: Journal of the Korean Physical Society, Vol. 74, No. 3, 01.02.2019, p. 286-291.

Research output: Contribution to journal › Article › peer-review

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T1 - X-ray Attenuation Properties of Ultrasmall Yb 2 O 3 Nanoparticles as a High-Performance CT Contrast Agent

AU - Ghazanfari, Adibehalsadat

AU - Marasini, Shanti

AU - Tegafaw, Tirusew

AU - Ho, Son Long

AU - Miao, Xu

AU - Ahmad, Mohammad Yaseen

AU - Yue, Huan

AU - Lee, Gang Ho

AU - Park, Ji Ae

AU - Jung, Ki Hye

AU - Chang, Yongmin

AU - Oh, In Taek

AU - Chae, Kwon Seok

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AB - Ultrasmall heavy metal-oxide nanoparticles can be utilized for highly enhancing contrasts in computed tomography (CT). In this study, ultrasmall Yb 2 O 3 nanoparticles coated with biocompatible and hydrophilic D-glucuronic acid were for the first time prepared through a simple one-step polyol process, and their X-ray attenuation properties were investigated by measuring phantom images and X-ray attenuation powers. The average particle diameter of the nanoparticles was estimated to be 2.1 ± 0.1 nm by using transmission electron microscopy. The observed X-ray attenuation power was stronger than that of a commercial iodine CT contrast agent (i.e., Ultravist®) at the same atomic concentration and much stronger at the same number density, proving the potential of ultrasmall Yb 2 O 3 nanoparticles for use as a powerful CT contrast agent.

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Ghazanfari A, Marasini S, Tegafaw T, Ho SL, Miao X, Ahmad MY et al. X-ray Attenuation Properties of Ultrasmall Yb ₂ O ₃ Nanoparticles as a High-Performance CT Contrast Agent Journal of the Korean Physical Society. 2019 Feb 1;74(3):286-291. doi: 10.3938/jkps.74.286

X-ray Attenuation Properties of Ultrasmall Yb ₂ O ₃ Nanoparticles as a High-Performance CT Contrast Agent

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