X-ray Attenuation Properties of Ultrasmall Yb                         2                         O                         3                          Nanoparticles as a High-Performance CT Contrast Agent

Adibehalsadat Ghazanfari; Shanti Marasini; Tirusew Tegafaw; Son Long Ho; Xu Miao; Mohammad Yaseen Ahmad; Huan Yue; Gang Ho Lee; Ji Ae Park; Ki Hye Jung; Yongmin Chang; In Taek Oh; Kwon Seok Chae

doi:10.3938/jkps.74.286

X-ray Attenuation Properties of Ultrasmall Yb ₂ O ₃ Nanoparticles as a High-Performance CT Contrast Agent

Adibehalsadat Ghazanfari
, Shanti Marasini
, Tirusew Tegafaw
, Son Long Ho
, Xu Miao
, Mohammad Yaseen Ahmad
, Huan Yue
, Gang Ho Lee
, Ji Ae Park
, Ki Hye Jung
, Yongmin Chang
, In Taek Oh
, Kwon Seok Chae

Kyungpook National University
Korea Institute of Radiological and Medical Sciences

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Ultrasmall heavy metal-oxide nanoparticles can be utilized for highly enhancing contrasts in computed tomography (CT). In this study, ultrasmall Yb ₂ O ₃ nanoparticles coated with biocompatible and hydrophilic D-glucuronic acid were for the first time prepared through a simple one-step polyol process, and their X-ray attenuation properties were investigated by measuring phantom images and X-ray attenuation powers. The average particle diameter of the nanoparticles was estimated to be 2.1 ± 0.1 nm by using transmission electron microscopy. The observed X-ray attenuation power was stronger than that of a commercial iodine CT contrast agent (i.e., Ultravist®) at the same atomic concentration and much stronger at the same number density, proving the potential of ultrasmall Yb ₂ O ₃ nanoparticles for use as a powerful CT contrast agent.

Original language	English
Pages (from-to)	286-291
Number of pages	6
Journal	Journal of the Korean Physical Society
Volume	74
Issue number	3
DOIs	https://doi.org/10.3938/jkps.74.286
State	Published - 1 Feb 2019

Keywords

CT contrast agent
Ultrasmall nanoparticle
Yb O

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10.3938/jkps.74.286

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Ghazanfari, A., Marasini, S., Tegafaw, T., Ho, S. L., Miao, X., Ahmad, M. Y., Yue, H., Lee, G. H., Park, J. A., Jung, K. H., Chang, Y., Oh, I. T., & Chae, K. S. (2019). X-ray Attenuation Properties of Ultrasmall Yb ₂ O ₃ Nanoparticles as a High-Performance CT Contrast Agent Journal of the Korean Physical Society, 74(3), 286-291. https://doi.org/10.3938/jkps.74.286

Ghazanfari, Adibehalsadat ; Marasini, Shanti ; Tegafaw, Tirusew et al. / X-ray Attenuation Properties of Ultrasmall Yb ₂ O ₃ Nanoparticles as a High-Performance CT Contrast Agent In: Journal of the Korean Physical Society. 2019 ; Vol. 74, No. 3. pp. 286-291.

@article{a3e86a4d4cf74c4bbeea3660c07649b9,

title = " X-ray Attenuation Properties of Ultrasmall Yb 2 O 3 Nanoparticles as a High-Performance CT Contrast Agent ",

abstract = " Ultrasmall heavy metal-oxide nanoparticles can be utilized for highly enhancing contrasts in computed tomography (CT). In this study, ultrasmall Yb 2 O 3 nanoparticles coated with biocompatible and hydrophilic D-glucuronic acid were for the first time prepared through a simple one-step polyol process, and their X-ray attenuation properties were investigated by measuring phantom images and X-ray attenuation powers. The average particle diameter of the nanoparticles was estimated to be 2.1 ± 0.1 nm by using transmission electron microscopy. The observed X-ray attenuation power was stronger than that of a commercial iodine CT contrast agent (i.e., Ultravist{\textregistered}) at the same atomic concentration and much stronger at the same number density, proving the potential of ultrasmall Yb 2 O 3 nanoparticles for use as a powerful CT contrast agent.",

keywords = "CT contrast agent, Ultrasmall nanoparticle, Yb O",

author = "Adibehalsadat Ghazanfari and Shanti Marasini and Tirusew Tegafaw and Ho, \{Son Long\} and Xu Miao and Ahmad, \{Mohammad Yaseen\} and Huan Yue and Lee, \{Gang Ho\} and Park, \{Ji Ae\} and Jung, \{Ki Hye\} and Yongmin Chang and Oh, \{In Taek\} and Chae, \{Kwon Seok\}",

note = "Publisher Copyright: {\textcopyright} 2019, The Korean Physical Society.",

year = "2019",

month = feb,

day = "1",

doi = "10.3938/jkps.74.286",

language = "English",

volume = "74",

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Ghazanfari, A, Marasini, S, Tegafaw, T, Ho, SL, Miao, X, Ahmad, MY, Yue, H, Lee, GH, Park, JA, Jung, KH, Chang, Y, Oh, IT & Chae, KS 2019, ' X-ray Attenuation Properties of Ultrasmall Yb ₂ O ₃ Nanoparticles as a High-Performance CT Contrast Agent ', Journal of the Korean Physical Society, vol. 74, no. 3, pp. 286-291. https://doi.org/10.3938/jkps.74.286

X-ray Attenuation Properties of Ultrasmall Yb ₂ O ₃ Nanoparticles as a High-Performance CT Contrast Agent . / Ghazanfari, Adibehalsadat; Marasini, Shanti; Tegafaw, Tirusew et al.
In: Journal of the Korean Physical Society, Vol. 74, No. 3, 01.02.2019, p. 286-291.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - X-ray Attenuation Properties of Ultrasmall Yb 2 O 3 Nanoparticles as a High-Performance CT Contrast Agent

AU - Ghazanfari, Adibehalsadat

AU - Marasini, Shanti

AU - Tegafaw, Tirusew

AU - Ho, Son Long

AU - Miao, Xu

AU - Ahmad, Mohammad Yaseen

AU - Yue, Huan

AU - Lee, Gang Ho

AU - Park, Ji Ae

AU - Jung, Ki Hye

AU - Chang, Yongmin

AU - Oh, In Taek

AU - Chae, Kwon Seok

PY - 2019/2/1

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AB - Ultrasmall heavy metal-oxide nanoparticles can be utilized for highly enhancing contrasts in computed tomography (CT). In this study, ultrasmall Yb 2 O 3 nanoparticles coated with biocompatible and hydrophilic D-glucuronic acid were for the first time prepared through a simple one-step polyol process, and their X-ray attenuation properties were investigated by measuring phantom images and X-ray attenuation powers. The average particle diameter of the nanoparticles was estimated to be 2.1 ± 0.1 nm by using transmission electron microscopy. The observed X-ray attenuation power was stronger than that of a commercial iodine CT contrast agent (i.e., Ultravist®) at the same atomic concentration and much stronger at the same number density, proving the potential of ultrasmall Yb 2 O 3 nanoparticles for use as a powerful CT contrast agent.

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KW - Ultrasmall nanoparticle

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Ghazanfari A, Marasini S, Tegafaw T, Ho SL, Miao X, Ahmad MY et al. X-ray Attenuation Properties of Ultrasmall Yb ₂ O ₃ Nanoparticles as a High-Performance CT Contrast Agent Journal of the Korean Physical Society. 2019 Feb 1;74(3):286-291. doi: 10.3938/jkps.74.286

X-ray Attenuation Properties of Ultrasmall Yb ₂ O ₃ Nanoparticles as a High-Performance CT Contrast Agent

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Keywords

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